ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE WATER EXTRACT FROM TERMINALIA CHEBULA REZT.

Authors

  • Seewaboon Sireeratawong Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Klong 1, Klong Loung, Pathum Thani 12120, Thailand
  • Kanjana Jaijoy McCormick Faculty of Nursing, Payap University, Chiang Mai 50000, Thailand.
  • Parirat Khonsung Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
  • Noppamas Soonthornchareonnon Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.

DOI:

https://doi.org/10.21010/ajtcam.v11i6.8

Keywords:

Terminalia chebula Retz., analgesic activity, anti-inflammatory activity

Abstract

Background: In ayurvedic and Thai traditional medicine, the fruit of T. chebula is useful in arthritic disorders, inflammation, tumor, pains, chronic and recurrent fever. The study investigated the analgesic and anti-inflammatory activities in animal models. Materials and methods: The water extract of T. chebula fruit was prepared and pain induced in mice by 0.1% formalin, before testing for the analgesic activity of the extract. The anti-inflammatory study was conducted in rats using four experimental models; ethyl phenylpropiolate or arachidonic acid-induced ear edema, carrageenan-induced paw edema and cotton pellet-induced granuloma formation. Results: The T. chebula extract decreased licking times in mice injected with 0.1% formalin in both the early and late phases. Moreover, the extract inhibited rat ear edema induced by ethyl phenylpropiolate as well as in carrageenan-induced paw edema. In contrast, the extract did not have any inhibitory effect on arachidonic acid-induced ear edema in rats. The T. chebula extract did not reduce granuloma weight, body weight gain and thymus dry weight in cotton pellet-induced granuloma formation. Conclusion: These results likely suggest that T. chebula water extract possess both analgesic and anti-inflammatory activities. The main mechanisms of action of T. chebula water extract may be due to the inhibitory effect on the synthesis and/or release of pain or inflammatory mediators

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Published

2014-10-15

How to Cite

Sireeratawong, S., Jaijoy, K., Khonsung, P., & Soonthornchareonnon, N. (2014). ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF THE WATER EXTRACT FROM TERMINALIA CHEBULA REZT. African Journal of Traditional, Complementary and Alternative Medicines, 11(6), 77–82. https://doi.org/10.21010/ajtcam.v11i6.8

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Section

Research Papers

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