ACUTE AND CHRONIC TOXICITY STUDIES OF THE WATER EXTRACT FROM DRIED FRUITS OF TERMINALIA BELLERICA (GAERTN.) ROXB. IN SPARGUE-DAWLEY RATS

Authors

  • Seewaboon Sireeratawong Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Klong 1, Klong Loung, Pathum Thani 12120, Thailand
  • Kanjana Jaijoy Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
  • Watcharin Panunto Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
  • Urarat Nanna Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
  • Nirush Lertprasertsuke Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
  • Noppamas Soonthornchareonnon Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.

Keywords:

Terminalia bellerica, acute toxicity, chronic toxicity

Abstract

Acute and chronic toxicities of the water extract from the dried fruits of Terminalia bellerica (Gaertn.) Roxb. were assessed in both female and male rats. For the study of acute toxicity, a single oral administration of the water extract at a dose of 5,000 mg/kg body weight (10 female, 10 male) was performed and the results showed no signs of toxicity such as general behavior changes, morbidity, mortality, changes on gross appearance or histopathological changes of the internal organs of rats. The study of chronic toxicity was determined by oral feeding both female and male rats (10 female, 10 male) daily with the test substance at the dose of 300, 600 and 1,200 mg/kg body weight continuously for 270 days. The examinations of signs of toxicity showed no abnormalities in the test groups compared to the controls. In addition, these rats were analyzed for final body and organ weights, necropsy, as well as hematological, blood chemical and histopathological parameters. Taken together, the water extract from the dried fruits of T. bellerica did not cause acute or chronic toxicities in either female or male rats.

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Published

2012-12-11

How to Cite

Sireeratawong, S., Jaijoy, K., Panunto, W., Nanna, U., Lertprasertsuke, N., & Soonthornchareonnon, N. (2012). ACUTE AND CHRONIC TOXICITY STUDIES OF THE WATER EXTRACT FROM DRIED FRUITS OF TERMINALIA BELLERICA (GAERTN.) ROXB. IN SPARGUE-DAWLEY RATS. African Journal of Traditional, Complementary and Alternative Medicines, 10(2), 223–231. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1589

Issue

Vol. 10 No. 2 (2013)

Section

Research Papers

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