EVALUATION OF ACUTE AND SUBACUTE ORAL TOXICITY OF THE ETHANOL EXTRACT FROM ANTIDESMA ACIDUM RETZ.

Authors

  • Seewaboon Sireeratawong Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Klong 1, Klong Loung, Pathum Thani 12120, Thailand
  • Sopit Thamaree Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
  • Kornkanok Ingkaninan Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
  • Pritsana Piyabhan Division of Physiology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand
  • Supaporn Vannasiri
  • Parirat Khonsung
  • Tipaya Singhalak Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
  • Kanjana Jaijoy

Keywords:

Antidesma acidum, Acute toxicity, Subacute toxicity

Abstract

Toxicity tests of 95% ethanol extract of the root of Antidesma acidum were studied in male and female rats. The oral acute toxicity test at 5,000 mg/kg revealed that the ethanol extract did not produce toxic effects on signs, general behavious, mortality and gross appearance of internal organs of rats. Furthermore, the oral sub-acute toxicity test at the dose of 1,000 mg/kg/day displayed no significant changes in body and internal organs’ weights, normal hematological and clinical blood chemistry values. Histological examination also showed normal architecture of all internal organs. In conclusion, the ethanol extract of Antidesma acidum did not produce any toxicity in oral acute and suba-cute toxicity studies.

Author Biographies

Supaporn Vannasiri

Division of Physiology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand

Parirat Khonsung

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Kanjana Jaijoy

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

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Published

2012-05-21

How to Cite

Sireeratawong, S., Thamaree, S., Ingkaninan, K., Piyabhan, P., Vannasiri, S., Khonsung, P., Singhalak, T., & Jaijoy, K. (2012). EVALUATION OF ACUTE AND SUBACUTE ORAL TOXICITY OF THE ETHANOL EXTRACT FROM ANTIDESMA ACIDUM RETZ. African Journal of Traditional, Complementary and Alternative Medicines, 9(4), 465–469. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1514

Issue

Vol. 9 No. 4 (2012)

Section

Research Papers

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