ACUTE AND SUBCHRONIC TOXICITY OF CHANTALEELA RECIPE IN RATS

Authors

  • Seewaboon Sireeratawong Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Klong 1, Klong Loung, Pathum Thani 12120, Thailand
  • Nattakarn Chiruntanat Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
  • Urarat Nanna Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.
  • Nirush Lertprasertsuke, Department of Pathology, Faculty of Medicine, Chiang Mai University, Muang, Chiang Mai 50200, Thailand.
  • Supachai Srithiwong Department of Animal Science, Faculty of Agricultural Technology, Chiang Mai Rajabhat University, Chiang Mai, 50300 Thailand.
  • Noppamas Soonthornchareonnon Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
  • Kanjana Jaijoy Research Unit of Pharmacology and Toxicology of Natural Products, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.

Keywords:

Acute toxicity, Subchronic toxicity, Chantaleela recipe

Abstract

Acute and subchronic toxicities of Chantaleela recipe were studied in both male and female rats. Oral administration of the extract at a single dose of 5,000 mg/kg body weight (5 females, 5 males) did not produce signs of toxicity, behavioral changes, mortality or differences on gross appearance of internal organs. The subchronic toxicity was determined by oral feeding the test substance at the doses of 600, 1,200 and 2,400 mg/kg body weight for 90 days (10 females, 10 males). No signs of abnormalities were observed in the test groups as compared to the controls. The test and control groups (on the 90th day) and the satellite group (on the 118th day) were analyzed by measuring their final body and organ weights, taking necropsy, and examining hematological parameters, blood clinical chemistry and histopathology features. The results suggest that Chantaleela recipe did not cause acute or subchronic oral toxicities to female and male rats.

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Published

2012-09-22

How to Cite

Sireeratawong, S., Chiruntanat, N., Nanna, U., Lertprasertsuke, N., Srithiwong, S., Soonthornchareonnon, N., & Jaijoy, K. (2012). ACUTE AND SUBCHRONIC TOXICITY OF CHANTALEELA RECIPE IN RATS. African Journal of Traditional, Complementary and Alternative Medicines, 10(1), 128–133. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1516

Issue

Vol. 10 No. 1 (2013)

Section

Research Papers

License

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