POTENTIAL ADMINISTRATION OF LIPOIC ACID AND COENZYME Q AGAINST ADIPOGENSIS: TARGET FOR WEIGHT REDUCTION
DOI:
https://doi.org/10.21010/ajtcam.v14i1.29Keywords:
lipolysis, obesity, lipoic acid, Co-QAbstract
Background: Body overweight and obesity were considered as a risk factor for many systemic diseases as diabetic hypertension, cardiovascular diseases, and some cancers. The lipoic acid and Co Q are considered as coenzymes needed for enhancement metabolic rate. The goal of this study is to evaluate the anti-obese effect of lipoic acid alone or combined with Co-Q in rats. Materials and Methods: Ninety male albino rats (100–150g) were used in this study, divided into six groups (15 each). Group I: Normal rats fed normal diet. Group II: Rats fed high fat diet (HFD). Group III: Rats fed HFD were given lipoic acid (10 μg/kg b w /day) intra-gastric by stomach tube. Group IV: Rats fed HFD were given Co-Q (10 μg /kg b.w/day) intra-gastric. Group V: Rats fed HFD were given lipoic acid (50 mg/kg b w /day) and Co-Q (10 μg /kg b. w/day). Group VI: Rats were given orlistat intra-gastric (10 mg/kg b w/day) as positive control for 6 weeks. Serum was subjected for determination of lipid profile, liver function tests atherogenic factor and lipoprotein lipase. Results: It was found that treatment with lipoic acid or Co-Q or combined showed increase in the activity of lipoprotein lipase (Downloads
Published
2016-11-23
How to Cite
AL-Ghamdi, M. A., Choudhry, H., AL-Doghather, H. A., Huwait, E. H., Kumosani, T. A., & Moselhy, S. S. (2016). POTENTIAL ADMINISTRATION OF LIPOIC ACID AND COENZYME Q AGAINST ADIPOGENSIS: TARGET FOR WEIGHT REDUCTION. African Journal of Traditional, Complementary and Alternative Medicines, 14(1), 272–277. https://doi.org/10.21010/ajtcam.v14i1.29
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Research Papers
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