MODULATION OF CARCINOGEN-METABOLIZING ENZYME BY MADINAH MINT (Mentha spp) IN RAT LIVER

Authors

  • Abdulrahman L. Al-Malki
  • Elie K. Barbour
  • Huwait E A
  • Said S. Moselhy
  • Hani Choudhry

DOI:

https://doi.org/10.21010/ajtcam.v13i6.7

Keywords:

Carcinogen-PAH-Cytochrome P450

Abstract

Background: The present study was undertaken to assess whether boiling water mint extract (BWME) modulates the cytochrome P450 mixed function oxidase system. Materials and methods: Male albino rats were randomly divided into two groups, comprising 12 animals each. The first group served as control, whereas the second was maintained on BWME (10 % w/v) as its sole drinking liquid for six weeks. Liver microsomal were separated and subjected for phase I and II enzymes (cytochrome P450 mixed function oxidase) analysis Results The results obtained showed that, BWME caused a significant elevation in the activity of epoxide hydrolase (p<0.001) when compared with the control. However, glutathione S-transferase and glucuronosyl transferase activities were significantly decreased (p<0.001 and p<0.01) respectively compared with control. The mutagenic activity of N-nitrosopiperidine was lower in the minttreated hepatic microsomal compared with the controls. Conclusion: It can be concluded that BWME has the potential to suppress the activity of cytochrome enzymes involved in the bioactivation of chemical carcinogen; hence may display chemo preventive activity.

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Published

2016-09-29

How to Cite

Al-Malki, A. L., Barbour, E. K., A, H. E., Moselhy, S. S., & Choudhry, H. (2016). MODULATION OF CARCINOGEN-METABOLIZING ENZYME BY MADINAH MINT (Mentha spp) IN RAT LIVER. African Journal of Traditional, Complementary and Alternative Medicines, 13(6), 32–37. https://doi.org/10.21010/ajtcam.v13i6.7

Issue

Vol. 13 No. 6 (2016)

Section

Research Papers

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