BALANITES AEGYPTIACA PROTECTION AGAINST PROLIFERATION OF DIFFERENT CANCER CELL LINE
DOI:
https://doi.org/10.4314/ajtcam.v13i2.2Keywords:
antiproliferative, apoptosis, Balanites aegyptiacaAbstract
Background: The aim of the present study was to evaluate in vivo anti-tumor activity of Balanites aegyptiaca fruits extracts in addition to its role in cell cycle and apoptosis. Materials and Methods: Antitumor activities of ethylacetae extract (EAE), ethanol extract (EE) and chloroform extract (CE) were tested against different cell line Hep-2, MCF-7, HL-60 and HCV29T. Calculation of the IC50 values for these extracts confirmed that the most potent plant extract was EAE (40 ug/ml) followed by EE (55ug/ml), CE (61ug/ml). Results: The ethanolic and chloroform extracts showed lower difference in their potency, while the EAE was found to be more active indicating for nonpolar active principles responsible for the anti-proliferative activity. The ethanolic extract was three times higher active than the chloroform extract. The results obtained showed that EAE exert a significant anti-proliferative, enhancement of apoptosis and modulation of cell cycle phases compared with vincristine. Conclusion: The presence of alkaloids, flavonoids and Phenolics increase its efficiency as anti-proliferative action. EAE has promising anti-cancer activity with higher activity than EE or CE extractsDownloads
Published
2016-02-05
How to Cite
Al-Malki, A. L., Barbour, E. K., Abulnaja, K. O., Moselhy, S. S., Kumosani, T. A., & Choudhry, H. (2016). BALANITES AEGYPTIACA PROTECTION AGAINST PROLIFERATION OF DIFFERENT CANCER CELL LINE. African Journal of Traditional, Complementary and Alternative Medicines, 13(2), 25–30. https://doi.org/10.4314/ajtcam.v13i2.2
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Section
Research Papers
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