ANTI-HYPERTENSIVE AND CARDIOVASCULAR EFFECTS OF TAPINANTHUS DODONEIFOLIUS (DC. DANSER) (LORANTHACEAE) IN RATS.

Authors

  • S. Ouedraogo
  • L. Belemnaba
  • B. Bucher
  • I. P. Guissou

Abstract

The hypotensive and anti-hypertensive effects of aqueous extract from Tapinanthus dodoneifolius (AETD) were examined in rats. Intravenous administrations of the plant extract (AETD 10-4 to 310-1 µg/kg iv) caused transient, dose-dependent and significant (p<0.05) reductions in basal arterial pressure of anaesthetised normotensive rats. Further more AETD (310-1 µg/kg) completely abolished adrenalin or phenylephrine evoked-hypertension on rats. The cardiovascular effects were then investigated. AETD did not affect heart rate, but significantly enhanced heart contraction force and relaxation capacity. Cumulative additions of T dodoneifolius aqueous extract (AETD 0.001- 1mg/ml) to the bath fluid induced concentration-dependent relaxation of endothelium-containing normotensive Wistar rat isolated aortic rings pre-contracted with phenylephrine (10-6M). The vasorelaxant effect of AETD on endothelium-containing isolated aortic rings was annulled by removal of the functional endothelium. When Indomethacin failed to inhibit AETD vasodilatory activity, pretreatment of the endothelium-containing vessels with NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS) completely abolished this vasodilatory effect. The findings of this experimental animal study suggest that T. dodoneifolius aqueous extract possess anti-hypertensive properties; this effect of the plant extract is likely to be mediated, at least in part, through vasorelaxant effect, through nitric oxide synthase activation and subsequent nitric oxide release.

Author Biography

S. Ouedraogo

Health Sciences Research Institute, Burkina Faso, osylvin@yahoo.fr

Published

2009-05-04

How to Cite

Ouedraogo, S., Belemnaba, L., Bucher, B., & Guissou, I. P. (2009). ANTI-HYPERTENSIVE AND CARDIOVASCULAR EFFECTS OF TAPINANTHUS DODONEIFOLIUS (DC. DANSER) (LORANTHACEAE) IN RATS. African Journal of Traditional, Complementary and Alternative Medicines, 6, 457–458. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/896