ENDOMETRIAL AND HORMONAL CHANGES IN RATS FOLLOWING ADMINISTRATION OF FENUGREEK EXTRACTED DIOSGENIN

Authors

  • I. Sulaiman
  • A. Nimir
  • S. Das

Abstract

Fenugreek (Trigonella foenum graecum L.) is an annual plant of the family Leguminosae. The seeds possess significant hypoglycemic, anti-atherosclerotic, anti-inflammatory, anti-ulcerogenic, and anti-neoplastic effects. The most potent component extracted from this herb is diosgenin. A total of 40 healthy female Norway albino rats aged between 7-11 weeks, having regular estrous cycles, were used in this study. Twenty rats assigned to the control group (GI) were administred 4ml of distilled water. The other twenty rats (GII) were given diosgenin (0.024mg/g body weight) suspended in 4ml of distilled water daily for 14 days through oro-gastric tube. Upon completion of 14 days of treatment, a blood sample was taken for hormonal assay and the animals were sacrificed thereafter. There was a significant increase in serum hormones (estrogen, progesterone and prolactin) in the studied group as compared to control one. Histological analysis showed that there was an increase in thickness and hyperactivity of the endometrium, increase in mucin secretion in addition to the increase in eosinophil and metrial glands count. The above changes, which were dose and duration dependant, may account for diosgenin use as a contraceptive or anti-infertility agent. Acknowledgements: Department of Anatomy, University of Baghdad

Author Biography

I. Sulaiman

Universiti Kebangsaan Malaysia, Malaysia, dr_israa70@yahoo.com

Published

2009-05-04

How to Cite

Sulaiman, I., Nimir, A., & Das, S. (2009). ENDOMETRIAL AND HORMONAL CHANGES IN RATS FOLLOWING ADMINISTRATION OF FENUGREEK EXTRACTED DIOSGENIN. African Journal of Traditional, Complementary and Alternative Medicines, 6, 442–443. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/868

Issue

ABSTRACTS OF THE WORLD CONGRESS ON MEDICINAL AND AROMATIC PLANTS, CAPE TOWN NOVEMBER 2008

Section

Conference Abstracts

License

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