EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF DIOSPYROS CORDIFOLIA EXTRACT

Authors

  • S. Das
  • P. K. Haldar
  • G. Pramanik
  • S. P. Panda
  • S. Bera

Keywords:

Diospyros cordifolia, analgesic, anti-inflammatory

Abstract

In this study we evaluated the analgesic and anti- inflammatory activities of the methanol extract of stem bark of Diospyros cordifolia (MEDC) Roxb. The analgesic effects of the stem bark of the plant was assessed in mice using the tail-flick method while carrageenan, histamine and dextran induced paw oedema was used to study the antiinflammatory effects in rats. The MEDC exhibited significant (p<0.01) analgesic effects comparable to the reference drug diclofenac sodium. MEDC also was evaluated for its anti-inflammatory potential against carrageenan, histamine and dextran induced rat paw edema. The methanol extract (25 and 50 mg / kg body weight) exhibited significant (p<0.01) activity against all phlogistic agents used in a dose dependent manner. All these effects were compared with reference drug phenylbutazone (100 mg/kg body weight).

Author Biography

S. Das

Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha – 741222, Nadia, India

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Published

2010-09-14

How to Cite

Das, S., Haldar, P. K., Pramanik, G., Panda, S. P., & Bera, S. (2010). EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF DIOSPYROS CORDIFOLIA EXTRACT. African Journal of Traditional, Complementary and Alternative Medicines, 8(1), 11–14. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1165

Issue

Vol. 8 No. 1 (2011)

Section

Research Papers

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