PHARMACOLOGICAL EVALUATIONS FOR THE RELAXANT EFFECT OF THE HYDROALCOHOLIC EXTRACT OF TAPINANTHUS DODONEIFOLIUS ON RAT TRACHEA
Keywords:
Extract of Tapinanthus dodoneifolius (Tapidod), Trachea, Calcium.Abstract
The present study was designed to investigate the blocking of calcium by the hydroalcoholic extract of Tapinanthus dodoneifolius (Tapidod), "in vitro", on rat trachea. To evaluate this effect, the contractile activity of tracheal chains from Wistar Kyoto rats was isometrically recorded. On the isolated tracheal rings the extract produced the following effects: (a) a reduction of the contraction obtained by BaCl2, (b) a bronchorelaxing action, on strips precontracted by KCl, which was not influenced by TEA (3x10-3 M), (c) a concentration-dependent decrease of the spasm evoked by calcium chloride (CaCl2) in K+-rich Ca2+-free physiological salt solution, before and after intracellular calcium depletion (d), an inhibitory effect on contraction induced by acetylcholine in Ca2+-free Krebs-Heinseleit solution supplemented with EDTA (5x10-4M). It is concluded that: 1. The activation of the potassium channels does not play a significant role in the relaxant effect of Tapidod. 2. The antispasmodic property of Tapidod seems to be mediated by the blockade of intracellular Ca2+ release. 3. Most likely an inhibition of the intracellular Ca2+-regulating proteins is involved.Downloads
Published
2006-01-07
How to Cite
Ouedraogo, M., Ouedraogo, S., Ouedraogo, L., Traore, A., & Belemtougri, R. G. (2006). PHARMACOLOGICAL EVALUATIONS FOR THE RELAXANT EFFECT OF THE HYDROALCOHOLIC EXTRACT OF TAPINANTHUS DODONEIFOLIUS ON RAT TRACHEA. African Journal of Traditional, Complementary and Alternative Medicines, 2(2), 166 –. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/49
Issue
Section
Research Papers
License
Copyright: Creative Commons Attribution CC.
This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.
