SPASMOLYTIC EFFECTS OF AQUEOUS EXTRACT OF MIXTURE FROM AFRAMOMUMUM MELEGUETA (K SCHUM) – CITRUS AURANTIFOLIA (CHRISTM AND PANZER) ON ISOLATED TRACHEA FROM RAT

Authors

  • Judith F Ahounou
  • Geoffroy G Ouedraogo
  • Joachim D Gbenou
  • Sylvin Ouedraogo
  • Wilfrid K D D Agbodjogbe
  • Pierre H Dansou
  • Mansourou Moudachirou

Keywords:

Aframomum melegueta, Citrus aurantifolia, extract, bronchodilatory, spasmolytic, Rat trachea. Aframomum melegueta, Rat trachea.

Abstract

The spasmolytic properties of the aqueous extract of Aframomum melegueta (K Schum) and Citrus aurantifolia (Christm and Panzer) (AMCA) mixture were tested on isolated rat trachea. Inhibition of the contraction was observed the in presence of the AMCA (EC 50 = 1.80 ± 0.48 mg/mL) after a pre contraction of the trachea by acetylcholine (10 -5 M). With propranolol (10 -6 M), the spasmolytic activity of the mixture was inhibited and the concentration-response curve shifted to the right. The EC50 value was then 2.60 ± 0.41 mg/mL. AMCA also inhibited contraction induced by KCl (4.10 -2 M) with EC50 value = 1.86 ± 0.65 mg/mL. These results clearly show the relaxing effect of the aqueous extract on the isolated rat trachea. This effect involved some β-adrenergic receptor inhibition.

Author Biography

Sylvin Ouedraogo

3Institut de Recherche en Science de la Santé, Département Médecine et Pharmacopée Traditionnelles/Pharmacie, 03BP7192 Ouagadougou 03, Burkina Faso

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Published

2011-11-08

How to Cite

Ahounou, J. F., Ouedraogo, G. G., Gbenou, J. D., Ouedraogo, S., Agbodjogbe, W. K. D. D., Dansou, P. H., & Moudachirou, M. (2011). SPASMOLYTIC EFFECTS OF AQUEOUS EXTRACT OF MIXTURE FROM AFRAMOMUMUM MELEGUETA (K SCHUM) – CITRUS AURANTIFOLIA (CHRISTM AND PANZER) ON ISOLATED TRACHEA FROM RAT. African Journal of Traditional, Complementary and Alternative Medicines, 9(2), 228–233. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1442

Issue

Vol. 9 No. 2 (2012)

Section

Research Papers

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