ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF ETHANOL EXTRACT OF SYZYGIUM AROMATICUM FLOWER BUD IN WISTAR RATS AND MICE

Authors

  • Y. Tanko
  • A. Mohammed
  • M. A. Okasha
  • A. H. Umar
  • R. A. Magaji

Keywords:

Syzygium aromaticum flower bud, anti-inflammatory, anti-nociceptive, Anti-Inflammatory, Acetic acid-induced abdominal constriction.

Abstract

The ethanol extracts of Syzygium aromaticum flower bud were tested for anti-nociceptive and anti-inflammatory effects in mice and Wistar rats which were carried out using acetic acid-induced abdominal contractions in mice and formalin-induced hind paw edema in Wistar rats. Three doses of the ethanol extract (50, 100, and 200mg/kg body weight i.p.) were used for both studies. The extract had an LD50 of 565.7 mg/kg body weight intraperitoneally in mice. The extracts produced significant effect (P<0.05) at all the three doses. Similarly, the anti-nociceptive activity produced significant effects (P<0.05) at all the three doses of the extract. The result supports the local use of the plant in painful and inflammatory conditions.

Author Biography

Y. Tanko

Department of Human Physiology, ABU, Zaria.

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Published

2007-09-26

How to Cite

Tanko, Y., Mohammed, A., Okasha, M. A., Umar, A. H., & Magaji, R. A. (2007). ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF ETHANOL EXTRACT OF SYZYGIUM AROMATICUM FLOWER BUD IN WISTAR RATS AND MICE. African Journal of Traditional, Complementary and Alternative Medicines, 5(2), 209–212. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/352

Issue

Vol. 5 No. 2 (2008)

Section

Research Papers

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