ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF AQUEOUS LEAVES EXTRACT OF OCIMUM GRATISSIMUM ( LABIATE ) IN RODENTS.

Authors

  • Y. Tanko
  • G. M. Magaji
  • M. Yerima
  • R. A. Magaji
  • A. Mohammed

Keywords:

Ocimum grassitimum, anti-nociceptive, anti-inflammatory.

Abstract

The aqueous leaves extract of Ocimum gratissimum was investigated for anti-nociceptive and anti-inflammatory effects in mice and rats. The models used to study the effect on nociception are the acetic acid-induced abdominal constriction test, hot- plate method in mice. The anti-inflammatory effect was investigated employing the formalin-induced hind–paw oedema in rats. The extract caused a significant (p<0.05), dose-dependent inhibition of acetic acid-induced writhing and hot-plate method .The extract also exhibited anti-inflammatory effect which was significant (P<0.001) at all the three doses. .The intraperitoneal LD50 value of the extract was 1264.9mg/kg body weight in mice. Preliminary phytochemical screening revealed the presence of alkaloids, saponins, tannins and flavonoids. The results suggest the extract contained pharmacologically active principles, and supports the local application of the plant in painful and inflammatory conditions.

Author Biography

Y. Tanko

Department of Human Physiology, Ahmadu Bello University, Zaria

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Published

2007-09-26

How to Cite

Tanko, Y., Magaji, G. M., Yerima, M., Magaji, R. A., & Mohammed, A. (2007). ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF AQUEOUS LEAVES EXTRACT OF OCIMUM GRATISSIMUM ( LABIATE ) IN RODENTS. African Journal of Traditional, Complementary and Alternative Medicines, 5(2), 141–146. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/343

Issue

Vol. 5 No. 2 (2008)

Section

Research Papers

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