INFLUENCE OF CARDIOSPERMUM HALICACABUM LEAF EXTRACT ON MEMBRANE BOUND ENZYMES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Authors

  • Chinnadurai Veeramani Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia
  • Khalid S. Al-Numair
  • Govindasamy Chandramohan
  • Mohammed A. Alsaif
  • Kodukkur Viswanathan Pugalendi

DOI:

https://doi.org/10.21010/ajtcam.v12i3.8

Keywords:

Streptozotocin, blood glucose, diabetes, membrane-bound ATPases, Cardiospermum halicacabum

Abstract

Background: Cardiospermum halicacabum L. has been proven scientifically to possess anti-inflammatory, antihyperglycemic, antioxidant, antiglycation, analgesic and antipyretic activities. It also has been used in Ayurveda and folk medicine for the treatment of rheumatism, fever and earache. Objective: In the present study, we investigated whether the Cardiospermum halicacabum leaf extract (CHE) can improve the membrane bound enzymes activity by streptozotocin (STZ)-induced diabetic rats. Methods: Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ. The CHE was administered orally to normal and STZ-diabetic rats for 45 days. Results: There were a marked decrease in the activities of membrane bound phosphatases such as total ATPases, Na+/K+-ATPases, Mg2+-ATPases and Ca2+-ATPases in the erythrocytes and tissues of STZ-induced diabetic rats. Oral administration of CHE to diabetic rats significantly increased the activities of these enzymes towards near normalcy. Conclusions: Thus, the present study indicates that the beneficial role of membrane bound enzymes in STZ-induced diabetic rats. The antihyperglycemic, antioxidant and antihyperlipidemic properties of CHE (Veeramani et al., 2008; Veeramani et al., 2010) could be helpful to maintain the levels of membrane bound enzymes in STZ-induced diabetic rats showing the membrane stabilizing property of extract.

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Published

2015-04-04

How to Cite

Veeramani, C., Al-Numair, K. S., Chandramohan, G., Alsaif, M. A., & Pugalendi, K. V. (2015). INFLUENCE OF CARDIOSPERMUM HALICACABUM LEAF EXTRACT ON MEMBRANE BOUND ENZYMES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 12(3), 68–74. https://doi.org/10.21010/ajtcam.v12i3.8

Issue

Vol. 12 No. 3 (2015)

Section

Research Papers

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