MORIN, A FLAVONOID, ON LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN EXPERIMENTAL MYOCARDIAL ISCHEMIC RATS

Authors

  • Khalid S Al-Numair Department of Community Health Sciences College of Applied Medical Sciences King Saud University P.O. Box 10219, Riyadh 11433 Saudi Arabia
  • Govindasamy Chandramohan
  • Mohammed A. Alsaif
  • Chinnadurai Veeramani
  • Ahmed S El Newehy

Abstract

Background: Myocardial infarction affects a large population in the world. Lipid peroxide metabolism plays an important role in the pathology of myocardial infarction. Objective: The present study was designed to investigate the antioxidant potential of morin, a flavonoid in isoproterenol (ISO)-induced myocardial infarction (MI), in rats. Materials and Methods: Male albino Wistar rats were pre-treated with morin (40 mg/kg), daily for a period of 30 days. After the treatment period, ISO (85 mg/kg), was subcutaneously injected in rats at an interval of 24 h for 2 days. Results: ISO-administered rats showed elevated levels of thiobarbituric acid reactive substances (TBARS), and lipid hydro-peroxide (LOOH), in plasma and heart. Pretreatment with morin, the above changes were significantly reduced to near normal level. ISO-administered rats showed decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in heart. In addition, decrease the levels non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E in plasma and heart while ceruloplasmin in plasma. Conclusion: Pretreatment with morin, reversed these above biochemical changes towards normalcy. These findings revealed that, the morin possess antioxidant activity in experimentally induced cardiac toxicity.

Author Biographies

Khalid S Al-Numair, Department of Community Health Sciences College of Applied Medical Sciences King Saud University P.O. Box 10219, Riyadh 11433 Saudi Arabia

Assistant Professor Department of Community Health Sciences

Govindasamy Chandramohan

Department of Community Health Sciences College of Applied Medical Sciences King Saud University P.O. Box 10219, Riyadh 11433 Saudi Arabia

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Published

2014-03-28

How to Cite

Al-Numair, K. S., Chandramohan, G., Alsaif, M. A., Veeramani, C., & El Newehy, A. S. (2014). MORIN, A FLAVONOID, ON LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN EXPERIMENTAL MYOCARDIAL ISCHEMIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 11(3), 14–20. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/2276

Issue

Vol. 11 No. 3 (2014)

Section

Research Papers

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