NEW ANTITRYPANOSOMAL TETRANOTRITERPENOIDS FROM AZADIRACHTA INDICA

Authors

  • Mercy Githua
  • Ahmed Hassanali
  • Joseph Keriko
  • Mary Ndungu
  • Grace Murilla
  • Gathu Nyagah

Keywords:

Meliaceae, limonoids, Trypanosoma brucei rhodesiense, Azadirachta indica, antitrypanosomal activity

Abstract

Organic extracts of the leaves of Azadirachta indica A. Juss. yielded ten antitrypanosomal terpenoids. Three of these (1 – 3), are novel and are derivatives of nimbolide and nimbin. They were extracted from chloroform fraction of methanol extract. These compounds were found to exhibit strong antitrypanosomal activities against Trypanosoma brucei rhodesiense with MIC values ranging of 6.9, 15.6 and 7.8 µg/ml respectively and were more active than Cymerlarsan ( a standard drug), which had an MIC value of 187.5 µg/ml when tested against T. b. rhodesiense The structures were elucidated by spectroscopic methods including; NMR, MS, UV and IR.

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Published

2010-02-04

How to Cite

Githua, M., Hassanali, A., Keriko, J., Ndungu, M., Murilla, G., & Nyagah, G. (2010). NEW ANTITRYPANOSOMAL TETRANOTRITERPENOIDS FROM AZADIRACHTA INDICA. African Journal of Traditional, Complementary and Alternative Medicines, 7(3), 207–213. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/1023

Issue

Vol. 7 No. 3 (2010)

Section

Research Papers

License

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