TY - JOUR AU - Drioiche, Aziz AU - Benhlima, Nadia AU - Kharchouf, Samira AU - EL MAKHOUKHI, Fadoua AU - MEHANNED, Smahane AU - ADADI, Imad AU - AAZIZ, Hicham AU - Kouoh Elombo, Ferdinand AU - Gressier, Bernard AU - ETO, Bruno AU - Zair, Touriya PY - 2020/01/09 Y2 - 2024/03/28 TI - ANTIMICROBIAL AND ANTIRADICAL PROPERTIES OF HAMMADA SCOPARIA (POMEL) ILJIN JF - African Journal of Traditional, Complementary and Alternative Medicines JA - Afr J Tradit Complement Altern Med VL - 16 IS - 2 SE - Research Papers DO - 10.21010/Ajtcam.v16n2.1 UR - https://journals.athmsi.org/index.php/ajtcam/article/view/5397 SP - 1-14 AB - <p><strong>Background: </strong><em>Hammada scoparia </em>(Pomel) Iljin (HS), is commonly used by traditional healers in Morocco against microbial and fungal infections. We studied antimicrobial, antifungal and antiradical effects of organic extracts <em>in vitro</em> in order to confirm traditional utilization after phytochemical screening.</p><p><strong>Materials and methods:</strong> Aerial parts of HS have been extracted by hydro-distillation using Clevenger-type apparatus, and the chemical composition was realized by Gas Chromatography coupled with Mass Spectroscopy (GC/MS). The antioxidant activity has been evaluated using DPPH test, while the antimicrobial tests of HS extract were conducted on twenty-eight bacterial strains and antifungal on twelve fungal strains.</p><p><strong>Results: </strong>Chemical characterization of HS essential oils (EO) confirmed the presence of carvacrol (82,28%), p-cymene (2,52%), γ-terpinene (2,18%) and Z-caryophyllene (2,04%). Antimicrobial tests of HS extract showed a moderate antibacterial activity without antifungal effect. In addition, HS exhibited a very powerful antiradical activity with IC<sub>50</sub> = 1,2 mg/ml compared to that of ascorbic acid (IC<sub>50 </sub>= 0,5 mg/mL) and butylated hydroxyanisole (0,8 mg/mL).</p><p><strong>Conclusion</strong><strong>: </strong>To our knowledge, this is the first demonstration that HS directly inhibits the growth of microorganisms <em>in vitro</em>, and further validates its traditional use as an antiseptic by traditional Moroccan healers.</p> ER -