TY - JOUR AU - Mahmoudvand, Hossein AU - Beyranvand, Maryam AU - Nayebzadeh, Hassan AU - Fallahi, Shirzad AU - Mirbadie, Seyyed Reza AU - Kheirandish, Farnaz AU - Kayedi, Mohammad Hassan PY - 2017/10/01 Y2 - 2024/03/29 TI - CHEMICAL COMPOSITION AND PROPHYLACTIC EFFECTS OF SATURJA KHUZESTANICA ESSENTIAL OIL ON ACUTE TOXOPLASMOSIS IN MICE JF - African Journal of Traditional, Complementary and Alternative Medicines JA - Afr J Tradit Complement Altern Med VL - 14 IS - 5 SE - Research Papers DO - 10.21010/ajtcam.v14i5.7 UR - https://journals.athmsi.org/index.php/ajtcam/article/view/4853 SP - 49-55 AB - Background: Toxoplasma gondii is a widespread zoonotic protozoan that infects approximately one third of the globalhuman population and all other warm-blooded animals. The present study aims to evaluate the prophylactic effects ofSatureja khuzestanica essential oil (SKEO) on infected mice with acute toxoplasmosis.Materials and Methods: The components of the SKEO were identified by gas chromatography/mass spectroscopy(GC/MS). To evaluate the prophylactic effects of SKEO, mice were divided into four groups. (i) non-treated group, (ii)mice treated with olive oil once a day for two weeks, (iii) mice treated with SKEO at the dose of 0.2ml/kg once a dayfor two weeks, (iv) and mice orally treated with SKEO at the dose of 0.3 ml/kg once a day for two weeks. After 24 h(fifteenth day) mice in the groups of two-four were infected intraperitonealy with 10-4 tachyzoite of T. gondii, RHstrain. The mortality rate in all infected mice and the number of tachyzoites from infected mice were recorded.Results: The main components of SKEO were carvacrol (78.8%), thymol (7.5%), and beta-Bisabolene (1.2%).Findings of prophylactic effects revealed that mortality rate of infected mice was 8 days after oral administration ofSKEO at the concentration of 0.2 and 0.3ml/kg (P<0.05). In contrast, this value for control group was 5 days. Inaddition, SKEO significantly reduced the mean number of tachyzoites compared with control group (P<0.05). Nosignificant difference (P>0.05) was observed in the clinical chemistry and hematological parameters following oraladministrations of SKEO at the doses of 0.2 and 0.3 ml/kg for 14 days.Conclusion: The results showed the potential of SKEO as a natural source for the production of new prophylactic agentfor use in toxoplasmosis. ER -