HYPOTENSIVE EFFECTS AND ACUTE TOXICITY PROPERTY OF METHANOL EXTRACT OF BAISSEA AXILLARIS HAU. LEAF ON ANIMAL MODELS

Authors

  • M. Idu
  • O. Timothy

Abstract

The hypotensive and acute toxicity activities of methanol extract of B. axillaris leaves, obtained by Soxhlet extraction, were analyzed using animal models. The extract exhibited a dose-dependent reduction in rabbit blood pressure. Basal mean arterial pressure of 115.67±3.60 mmHg was progressively reduced to 106.22±3.13 and 69.3±2.59 mmHg by 2.5 and 20 mg kg-1 doses of extract respectively. Haematological parameters in Wister rats treated with 1, 2 and 4 g kg-1 of extract showed no significant difference (P>0.05). However, lethal dosage was obtained at 8 g kg-1. The results obtained showed that the extract has a blood pressure lowering effect.

Author Biography

M. Idu

University of Benin, Nigeria.

Published

2009-05-04

How to Cite

Idu, M., & Timothy, O. (2009). HYPOTENSIVE EFFECTS AND ACUTE TOXICITY PROPERTY OF METHANOL EXTRACT OF BAISSEA AXILLARIS HAU. LEAF ON ANIMAL MODELS. African Journal of Traditional, Complementary and Alternative Medicines, 6, 416. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/816

Issue

ABSTRACTS OF THE WORLD CONGRESS ON MEDICINAL AND AROMATIC PLANTS, CAPE TOWN NOVEMBER 2008

Section

Conference Abstracts

License

Copyright: Creative Commons Attribution CC.

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