TRYPANOCIDAL PROPERTIES OF TERMINALIA IVORENSIS A. Chev. (COMBRETACEAE)

Authors

  • Joseph M. Agedahunsi
  • Ivie Anao
  • Clement O. Adewunmi
  • Simon L. Croft

Keywords:

Terminalis ivorensis, Trypanosoma brucei rhodesiensis, trypanocidal

Abstract

Human African Trypanosomiasis (sleeping sickness) cause considerable mortality and morbidity throughout the world with Trypansoma brucei, T. gambiense and T. brucei rhodesiense as the major causative agents. The Terminalia ivorensis gradient extracts were tested against T. brucei rhodesiense parasites and the E.D50 values of 11.11 and 12.32 µg/mL were obtained for the ethyl acetate and ethanolic gradient extracts respectively. The column fractions of the ethyl acetate fraction gave E.D50 value between 1.98 and 5.46 µg/mL for the very active fractions indicating prospect for the development of potential trypanocidal agent from the plant.

Author Biographies

Joseph M. Agedahunsi

Drug Research & Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria

Ivie Anao

Pharmacognosy Research Laboratories, Department of Pharmacy, Kings College London, Franklin-Wilkins Building, 150 Stanford Street, London SE 1 9NN, U.K.

Clement O. Adewunmi

Drug Research & Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria

Simon L. Croft

Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street London WC 1E 7HT.UK

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Published

2006-01-12

How to Cite

Agedahunsi, J. M., Anao, I., Adewunmi, C. O., & Croft, S. L. (2006). TRYPANOCIDAL PROPERTIES OF TERMINALIA IVORENSIS A. Chev. (COMBRETACEAE). African Journal of Traditional, Complementary and Alternative Medicines, 3(2), 51–56. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/77

Issue

Vol. 3 No. 2 (2006)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

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