ANTIDIABETIC ACTIVITY OF ETHANOLIC LEAF EXTRACT OF CROTON ZAMBESICUS MUELL.(THUNDER PLANT) IN ALLOXAN DIABETIC RATS

Authors

  • J. E. Okonkon
  • A. L. Bassey
  • J. Obot

Keywords:

Croton zambesicus, antidiabetic, alloxan

Abstract

Antidiabetic activity of ethanolic leaf extract of Croton zambesicus Muell. Arg. was evaluated using alloxan-induced (150mg/kg) hyperglycaemic rats. The activity of the ethanolic leaf extract was compared with that of a reference drug Chlorpropamide. The Blood Glucose Levels were measured using glucometer. The extract produced a significant (P<0.01) reduction in BGL after a single dose of the extract and in prolonged treatment (for 7 days). The antidiabetic activity was comparable to that of the reference drug-chlorpropamide.

Author Biographies

J. E. Okonkon

Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

A. L. Bassey

Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

J. Obot

Department of Pharmacology & Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

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Published

2006-01-12

How to Cite

Okonkon, J. E., Bassey, A. L., & Obot, J. (2006). ANTIDIABETIC ACTIVITY OF ETHANOLIC LEAF EXTRACT OF CROTON ZAMBESICUS MUELL.(THUNDER PLANT) IN ALLOXAN DIABETIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 3(2), 21–26. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/73

Issue

Vol. 3 No. 2 (2006)

Section

Research Papers

License

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