TOXICITY OF ERYTHROPHLEUM GUINEENSE

Authors

  • B. A. Adeoye
  • O.` O. Oyedapo

Keywords:

Toxicity, hepatic, Erythrophelum guineese, alkaloidal fraction,

Abstract

The effect of the in vivo administration of the total alkaloidal fractions of the stem-bark of the Erythropleum guineense on certain biological parameters of Sprague-Dawley rats was investigated. The results revealed that plasma alanine aminotransferase activity, liver aspartate aminotransferase activity, liver glycogen, liver protein, creatinine and haemoglobin concentrations were reduced while plasma aspartate aminotransferase activity, liver alanine aminotransferase activity, plasma urea concentration, bilirubin concentration and alkaline phosphatase activity were elevated in Sprague -Dawley rats treated with total alkaloidal fractions of E. guineense stem-bark. The phytochemical assays revealed that the chemical composition of E. guineense include alkaloids, saponins, cardiac glycosides and tannins. The toxicity of the stem-bark of E. guineense could be attributed to the combined toxicity of other constituents such as tannins, saponins and glycosides with the alkaloids as earlier speculated.

Author Biographies

B. A. Adeoye

Department of Biochemistry, Obafemi Awolowo University Ile-Ife, Nigeria 220005

O.` O. Oyedapo

Department of Biochemistry, Obafemi Awolowo University Ile-Ife, Nigeria 220005

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Published

2006-01-07

How to Cite

Adeoye, B. A., & Oyedapo, O. O. (2006). TOXICITY OF ERYTHROPHLEUM GUINEENSE. African Journal of Traditional, Complementary and Alternative Medicines, 1(1), 45–54. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/64

Issue

Vol. 1 No. 1 (2004)

Section

Research Papers

License

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