MICROANATOMICAL EFFECTS OF ETHANOLIC EXTRACT OF COLA NITIDA ON THE STOMACH MUCOSA OF ADULT WISTAR RATS

Authors

  • G. B. Ojo
  • P. U. Nwoha
  • D. A. Ofusori
  • S. A. Ajayi
  • S. A. Odukoya
  • V. O. Ukwenya
  • O. Bamidele
  • O. A. Ojo
  • O. P. Oluwayinka

Keywords:

Cola nitida, necrotized, degenerated, stomach mucosa, microanatomy, glandular elements

Abstract

The study investigated the microanatomical effects of the extracts of Cola nitida on the stomach mucosa of adult male Wistar rats. Twenty adult male wistar rats were randomly divided into four equal groups of A, B, C and D (n=5). Animals in experimental groups B, C and D were given 600mg/kg body weight of crude extract of Cola nitida each by oral intubation for five, seven and nine consecutive days respectively, while group A (control) received equivalent volume of distilled water. Twenty four hrs after the last administration, the animals were sacrificed; tissues were harvested and fixed in 10% formol saline for histological analysis. The study revealed necrotized surface epithelium, degenerated gastric mucosa, and loss of glandular elements in the stomachs of experimental groups’ vis-à-vis the control group. These observations were days-dependent; as those groups which received the extract for higher number of days were seen to be adversely affected. In conclusion, Cola nitida at 600mg/kg body weight can cause gastric lesion in animals. This lesion may be pronounced if the administration continued for days. Cola nitida should, therefore, be taken with caution to avoid gastric complications.

Author Biographies

G. B. Ojo

Department of Anatomy and Cell Biology; Lecturer

D. A. Ofusori

Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Osun state, Nigeria

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Published

2009-08-15

How to Cite

Ojo, G. B., Nwoha, P. U., Ofusori, D. A., Ajayi, S. A., Odukoya, S. A., Ukwenya, V. O., Bamidele, O., Ojo, O. A., & Oluwayinka, O. P. (2009). MICROANATOMICAL EFFECTS OF ETHANOLIC EXTRACT OF COLA NITIDA ON THE STOMACH MUCOSA OF ADULT WISTAR RATS. African Journal of Traditional, Complementary and Alternative Medicines, 7(1), 47–52. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/632

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Section

Research Papers