METABOLIC SYNDROME: IN VITRO ANTIOXIDANT, ANTICANCER, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF DISSOTIS ROTUNDIFOLIA (SM.) WITH PHYTOCHEMICAL AND NUTRITIONAL COMPONENTS

Authors

  • Idayat Titilayo GBADAMOSI
  • Joseph Ayotunde BADEJO
  • Temitayo Olabisi AJIBADE
  • Akpevwoghene AGBATUTU
  • Ezekiel Ayodeji ABIARA
  • Akinlolu Tobi AKINKOYE
  • Emmanuel Oloruntoba YEYE
  • Ibukun Micheal FAMUYIDE
  • Lyndy Joy MCGAW
  • Sanah Malomile NKADIMENG
  • Ademola Adetokunbo OYAGBEMI
  • Temidayo Olutayo OMOBOWALE
  • Akindele Oluwatosin ADEYI
  • Oluwatoyin Adepeju ODEKU
  • Aishat Mojisola AKERE
  • Jemilat Aliyu IBRAHIM
  • Taoheed Kolawole MUFTAUDEEN

DOI:

https://doi.org/10.21010/AJTCAM%20v19i1.1

Keywords:

metabolic syndrome, antioxidant,

Abstract

Background: Dissotis rotundifolia (Sm.) Triana is a prostrate herb of the family Melastomataceae. It is used for the treatment of obesity, hypertension, circulatory problems and metabolic syndrome (MS). This study evaluated the antioxidant, anticancer, anti-inflammatory.and antimicrobial activities of the whole plant of D. rotundifolia to validate its therapeutic potential in the management and treatment of MS.

Materials and Methods: The plant was screened for proximate, mineral, vitamin and phytochemical components, as well as antioxidant activities using standard laboratory techniques. The anticancer activities of the ethanol plant extract were against kidney (VERO) and breast (MCF-7) cancer cells. The anti-inflammatory activity of the extract was determined using nitric oxide production inhibition assay and the antimicrobial activity was evaluated against five pathogenic organisms. All data were subjected to statistical analysis.

Results: The plant was rich in carbohydrate (47.87%), protein (22.5%), crude fibre (9.57%), Na (206.67mg/100g), Ca (183.33mg/100 g), vitamin C(25.53mg/100g), flavonoids (685.00mg/100g), alkaloids (616.67 mg/100g) and saponins (471.67 mg/100 g) contents. The extract exhibited considerable and varied antioxidant activities. The plant extract was very active against VERO and MCF-7 cells at low concentrations (0.145 mg/ml and 0.141 mg/ml respectively) compared to doxorubicin. It also exhibited significant anti-inflammatory action against lipopolysaccharide (LPS)-stimulated RAW macrophage. The extract was active against all test organisms. Overall, D. rotundifolia displayed significant antioxidant, anticancer, anti-inflammatory and antimicrobial activities.

Conclusion: The observed bioactivities of the plant could be attributed to its phytocontents and are indications of its potential as an agent for the management and treatment of metabolic syndrome.

 

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Published

2024-08-29

How to Cite

GBADAMOSI, I. T., BADEJO , J. A., AJIBADE, T. O., AGBATUTU , A., ABIARA , E. A., AKINKOYE , A. T., YEYE , E. O., FAMUYIDE , I. M., MCGAW , L. J., NKADIMENG , S. M., OYAGBEMI , A. A., OMOBOWALE , T. O., ADEYI , A. O., ODEKU , O. A., AKERE, A. M., IBRAHIM, J. A., & MUFTAUDEEN, T. K. (2024). METABOLIC SYNDROME: IN VITRO ANTIOXIDANT, ANTICANCER, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF DISSOTIS ROTUNDIFOLIA (SM.) WITH PHYTOCHEMICAL AND NUTRITIONAL COMPONENTS. African Journal of Traditional, Complementary and Alternative Medicines, 19(1), 16–24. https://doi.org/10.21010/AJTCAM v19i1.1

Issue

Vol. 19 No. 1 (2022)

Section

Review

License

Copyright (c) 2024 Idayat Titilayo GBADAMOSI, Joseph Ayotunde BADEJO , Temitayo Olabisi AJIBADE, Akpevwoghene AGBATUTU , Ezekiel Ayodeji ABIARA , Akinlolu Tobi AKINKOYE , Emmanuel Oloruntoba YEYE , Ibukun Micheal FAMUYIDE , Lyndy Joy MCGAW , Sanah Malomile NKADIMENG , Ademola Adetokunbo OYAGBEMI , Temidayo Olutayo OMOBOWALE , Akindele Oluwatosin ADEYI , Oluwatoyin Adepeju ODEKU , Aishat Mojisola AKERE, Jemilat Aliyu IBRAHIM, Taoheed Kolawole MUFTAUDEEN

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