ANTI-INFLAMMATORY ACTIVITY OF EXTRACTS OF ROOT BARK OF SECURIDACA LONGIPEDUNCULATA FRES (POLYGALACEAE)

Authors

  • C. O Okoli
  • P. A. Akah
  • U. Ezugworie

Keywords:

Securidaca longipedunculata, root bark, acute inflammation, systemic edema.

Abstract

The effect of extract and fractions of the root bark of Securidaca longipedunculata Fres (Polygalaceae) on acute inflammation was evaluated. Solvent extraction yielded the crude methanol extract (ME) while solvent–guided extraction yielded a petroleum ether fraction (PF) and methanol fraction (MF). The extract and fractions inhibited topical edema induced by xylene in the mouse ear. In the systemic edema of the rat paw, the methanol extract (ME) and methanol fraction (MF) significantly (P<0.05) suppressed the development of paw edema induced by egg albumin in rats while the petroleum ether fraction (PF) was devoid of such activity. Ulcerogenic assay in rats indicated that the extract and fractions exhibited varying degrees of gastric irritation in rats in the order of magnitude: MF > PF > ME. Phytochemical tests showed that ME and MF tested positive for carbohydrates, reducing sugars, glycosides, flavonoids, terpenoids, sterols and saponins while PF gave positive reaction for resins only. Acute toxicity test for ME in mice established an i.p and p.o LD50 of 11 and 282 mg/kg respectively.

Author Biographies

C. O Okoli

Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria

P. A. Akah

Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria

U. Ezugworie

Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria

Downloads

Published

2006-01-12

How to Cite

Okoli, C. O., Akah, P. A., & Ezugworie, U. (2006). ANTI-INFLAMMATORY ACTIVITY OF EXTRACTS OF ROOT BARK OF SECURIDACA LONGIPEDUNCULATA FRES (POLYGALACEAE). African Journal of Traditional, Complementary and Alternative Medicines, 3(1), 54–63. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/6

Issue

Vol. 3 No. 1 (2006)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.