ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF CASSIA FISTULA LINN BARK EXTRACTS

Authors

  • Raju Ilavarasan
  • Moni Malika
  • Subramanian Venkataraman

Keywords:

Cassia fistula, Anti-inflammatory, Antioxidant activity.

Abstract

Anti-inflammatory and Antioxidant activities of the aqueous (CFA) and methanolic extracts (CFM) of the Cassia fistula Linn. bark were assayed in wistar albino rats. The extracts were found to posses significant anti-inflammatory effect in both acute and chronic models. Cassia fistula bark extracts showed significant radical scavenging by inhibiting lipid peroxidation initiated by CCl4 and FeSO4 in rat liver and kidney homogenates. Both extracts exhibited significant antioxidant activity in DPPH, Nitric oxide and Hydroxyl radical induced invitro assay methods. Both extracts showed Dose-dependent protective effect against lipid peroxidation and free radical generation in liver and kidney homogenates. Further, the acute toxicity study with the extracts showed no sign of toxicity up to a dose level of 2000 mg/ po. Thus it could be concluded that Cassia fistula bark extracts (CFA & CFM) possess significant anti-inflammatory and anti oxidant properties.

Author Biographies

Raju Ilavarasan

Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Old Mahabalipuram Road, Jyothi Nagar, Thorapakkam, Chennai 600 096

Moni Malika

Department of Microbiology, Sri Ramachandra Medical College and Research Institute (Deemed University), Porur, Chennai-600 116

Subramanian Venkataraman

Department of Pharmacology and Environment Toxicology, Dr.A.L.Mudiliar P.G. Institute of Medical Sciences, University of Madras, Taramani, Chennai-600 113, India.

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Published

2006-01-07

How to Cite

Ilavarasan, R., Malika, M., & Venkataraman, S. (2006). ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF CASSIA FISTULA LINN BARK EXTRACTS. African Journal of Traditional, Complementary and Alternative Medicines, 2(1), 70–85. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/59

Issue

Vol. 2 No. 1 (2005)

Section

Research Papers

License

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