THE OPTIMAL EXTRACTION PARAMETERS AND ANTI-DIABETIC ACTIVITY OF FLAVONOIDS FROM IPOMOEA BATATAS LEAF

Authors

  • F. Li
  • Q. Li
  • D. Gao
  • Y. Peng

Keywords:

flavonoids from Ipomoea batatas leaf, extraction, anti-diabetic

Abstract

Extraction parameters of flavonoids from Ipomoea batatas leaf (FIBL) and anti-diabetic activity of FIBL on alloxan induced diabetic mice were studied. The optimal extraction parameters of FIBL were obtained by single factor test and orthogonal test, as follows: ethanol concentration 60 %, ratio of solvent to raw material 30 , extraction temperature 75 ℃ and extraction time 1.5 h , while extraction yield of FIBL was 5.94 %. FIBL treatment (50, 100, and 150 mg/ kg body weight) for 28 days resulted in a significant decrease in the concentration of fasting blood glucose (FBG), total cholesterol (TC) and triglyceride (TG) in diabetes mellitus mice. Furthermore, FIBL significantly increased body weight (bw) and serum high-density lipoprotein cholesterol (HDL-c) level. The data demonstrated FIBL at the dose of 100 mg/kg bw exhibited the optimal effect. The above results suggest that FIBL can control blood glucose and modulate the metabolism of blood lipid in diabetes mellitus mice.

Author Biography

F. Li

Department of Biological Engineering, Yanshan University, No.438 Hebei Street, Qinhuangdao 066004, P.R. China

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Published

2009-03-07

How to Cite

Li, F., Li, Q., Gao, D., & Peng, Y. (2009). THE OPTIMAL EXTRACTION PARAMETERS AND ANTI-DIABETIC ACTIVITY OF FLAVONOIDS FROM IPOMOEA BATATAS LEAF. African Journal of Traditional, Complementary and Alternative Medicines, 6(2), 195–202. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/576

Issue

Vol. 6 No. 2 (2009)

Section

Research Papers

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