ANTIPROLIFERATIVE EFFECT OF ALCOHOLIC EXTRACTS OF SOME GABONESE MEDICINAL PLANTS ON HUMAN COLONIC CANCER CELLS

Authors

  • M. Line-Edwige
  • Feuya Tchouya
  • Guy Raymond
  • E. Francois
  • N. Edouard

Keywords:

Cissus debilis, Dieffenbachia seguine, Petersianthus macrocarpus, Piptadeniastrum africanum, antiproliferative activity, CaCo-2 cells.

Abstract

Extracts from Piptadeniastrum africanum Brenan (Mimosaceae), Petersianthus macrocarpus (Breauv) L. (Lecydaceae), Cissus debilis Planch (Vitaceae) and Dieffenbachia seguine Jacq. (Araceae) were tested in vitro for their antiproliferative activity on human colon cancer cell line (CaCo-2). The highest antiproliferative activities were obtained with the alcoholic extracts of the roots of Piptadeniastrum africanum (G-PAR), the leaves of Petersianthus macrocarpus (G-PMF) and the stem of Cissus debilis (G-CDL), with 50% inhibition concentrations (IC50) of 15 µg/ml, 17 µg/ml and 25 µg/ml respectively. Only one extract (leaves of Dieffenbachia seguine (G-DSF)) exhibited weak antiproliferative activity with 50% inhibition concentration (IC50) higher than 50 µg/ml.

Author Biography

M. Line-Edwige

aLaboratoire de Phytochimie, Institut de Pharmacopée et de Médecine Traditionnelle (IPHAMETRA)/ CENAREST, BP 1935 Libreville / Gabon

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Published

2009-03-07

How to Cite

Line-Edwige, M., Tchouya, F., Raymond, G., Francois, E., & Edouard, N. (2009). ANTIPROLIFERATIVE EFFECT OF ALCOHOLIC EXTRACTS OF SOME GABONESE MEDICINAL PLANTS ON HUMAN COLONIC CANCER CELLS. African Journal of Traditional, Complementary and Alternative Medicines, 6(2), 112–117. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/567

Issue

Vol. 6 No. 2 (2009)

Section

Research Papers

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