EFFECTS OF TEPHROSIA PURPUREA AQUEOUS SEED EXTRACT ON BLOOD GLUCOSE AND ANTIOXIDANT ENZYME ACTIVITIES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Authors

  • P. Pavana
  • S. Sethupathy
  • K. Santha
  • S. Manoharan

Keywords:

Streptozotocin, Tephrosia purpurea, Antioxidants, Lipid peroxidation

Abstract

The aim of the present study was to evaluate the effects of aqueous seed extract of Tephrosia purpurea (TpASet) on blood glucose and antioxidant status in streptozotocin induced diabetic rats. Hyperglycemia associated with an altered hexokinase and glucose-6-phosphatase activities, elevated lipid peroxidation, disturbed enzymatic [Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] and non enzymatic [Glutathione, vitamin C and vitamin E] antioxidant status were observed in streptozotocin induced diabetic rats. Oral administration of “TpASet” at a dose of 600mg/kg body weight showed significant improvement in above mentioned parameters. Our results clearly indicate that “TpASet” has potent antihyperglycemic and antioxidant effects in streptozotocin-induced diabetic rats and therefore further studies are warranted to isolate and characterize the bioactive principles from “TpASet”.

Author Biography

S. Manoharan

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608002 Tamilnadu. INDIA.

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How to Cite

Pavana, P., Sethupathy, S., Santha, K., & Manoharan, S. (2008). EFFECTS OF TEPHROSIA PURPUREA AQUEOUS SEED EXTRACT ON BLOOD GLUCOSE AND ANTIOXIDANT ENZYME ACTIVITIES IN STREPTOZOTOCIN INDUCED DIABETIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 6(1), 78–86. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/500

Issue

Vol. 6 No. 1 (2009)

Section

Research Papers

License

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