ACUTE AND SUBACUTE ANTI-INFLAMMATORY ACTIVITIES OF DICHLOROMETHANE EXTRACT OF CASSIA ALATA (LINN.) LEAVES IN WISTAR RATS

Authors

  • F. L Da Laboratory of Animal Physiology, UFR of Life and Earth Sciences, University Ouaga I Pr Joseph KI-ZERBO, 03 BP 7021, Ouaga 03, Burkina Faso
  • A. B Keugni
  • G. R Belemtougri
  • T. L. A Fotio
  • T. Dimo

DOI:

https://doi.org/10.21010/ajtcam.vi15.1.18

Keywords:

Cassia alata, anti-inflammatory effect, animal models, edema, granuloma

Abstract

Background: In Burkina Faso, leaves of Cassia alata are used in the treatment of several diseases, including inflammation. This study evaluated the anti-inflammatory effects of the dichloromethane extract of Cassia alata leaves (CF-AECal) on different models of inflammation in wistar rats in order to enhance its use in traditional medicine. Materials and Methods: Acute inflammation was induced among rats with 0.1 ml of carrageenan, serotonin, histamine and dextrane 1%. The effects of the CF-AECal 50 mg/kg and 100 mg/kg were compared to the effects of diclofenal 5 mg/kg, prednisone 5 mg/kg, promethazine 1 mg/kg, cyproheptadin 2 mg/kg. Cotton pellet and air pouch - induced granuloma permitted to study CF-AECal effects on the subacute inflammation. The ways of administrations were intra peritoneal for the substances of inductions and oral for the molecules of references and CF-AECal. Result: Carrageenan-induced paw edema has been inhibited to 52.39% by CF-AECal 50 mg/kg and 50.17% by CF-AECal 100 mg/kg. Wet granulomas formation has been inhibited by CF-AECal 50 and 100 mg/kg to 20.94 and 57.82%. The dry granulomas were inhibited at 24.32 and 59.04% by CF-AECal 50 and 100 mg/kg. Air pouch fluid was significantly reduced by CF-AECal in comparison to the control group. There was a massive recruitment of leukocytes in the pocket granuloma of the control group. CF-AECal caused strong inhibition of this infiltration of leukocytes (p< 0.001). Conclusion: Dichloromethane extract of Cassia alata showed anti-inflammatory effects.

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Published

2017-12-29

How to Cite

Da, F. L., Keugni, A. B., Belemtougri, G. R., Fotio, T. L. A., & Dimo, T. (2017). ACUTE AND SUBACUTE ANTI-INFLAMMATORY ACTIVITIES OF DICHLOROMETHANE EXTRACT OF CASSIA ALATA (LINN.) LEAVES IN WISTAR RATS. African Journal of Traditional, Complementary and Alternative Medicines, 15(1), 174–182. https://doi.org/10.21010/ajtcam.vi15.1.18

Issue

Section

Research Papers

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