Vol 15 No 1 (2018)
Research Papers

POTENTIAL ANTITUMOR ACTIVITY OF CURCUMIN WITH RETINYLESTER MICRO-CAPSULED FORMULA

Jehan A. Khan
Department of Biology (Genomic Division), Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
Published December 29, 2017
Keywords
  • Curcumin –Retinylester- Microcapsules-Anticancer
How to Cite
Khan, J. A. (2017). POTENTIAL ANTITUMOR ACTIVITY OF CURCUMIN WITH RETINYLESTER MICRO-CAPSULED FORMULA. African Journal of Traditional, Complementary and Alternative Medicines, 15(1), 137-141. https://doi.org/10.21010/ajtcam.vi15.1.13

Abstract

Background: The Bioavailabilty, efficacy and disease resistance of chemotherapy are the limitations of cancer treatment. This study was designed to formulate a microcapsules containing curcumin and retinylester as core material and tested the anti-cancer activity against different cancer cell lines. Materials and methods: This study involved the design and formulation of microcapsules containing curcumin and retinylester as (core materials) embedded in dextrin/gelatin as wall materials. It was examined by Fourier-transform infrared spectroscopy FTIR and tested against HeLa and HepG2 cancer cell lines. Results: Analysis of microcapsule by FTIR showed the characteristic band (2000cm-1~ 3800cm-1) that is indicated mainly from OH-, – CH3 and double bond. These bond stretching showed spectral bands peak 2975cm-1and 2670cm-1, 2836cm-1 respectively. The anticancer activity of these microcapsules on HeLA and HepG2 showed inhibition percent 87% and 85% respectively and non-toxic effect on normal cells. Conclusion: Micro capsulated form of curcumin-retinylester showed an efficient medicinal mixture displayed a significant effect to HeLa and HepG2 cells which is very promising effective in the treatment of cancer.