ANTI-DIABETIC EFFECTS OF ZHUODUQING FORMULA, A CHINESE HERBAL DECOCTION, ON A RAT MODEL OF TYPE 2 DIABETES

Authors

  • Xiao-Tao Feng
  • Shu-Yan Tang
  • Yun-Xia Jiang
  • Wei Zhao

DOI:

https://doi.org/10.21010/ajtcam.v14i3.5

Keywords:

Insulin sensitivity, Chinese medicine, anti-diabetic effect, inflammatory factor, SOCS-3

Abstract

Background: Zhuoduqing formula (ZDQ) is a Chinese herbal decoction and used to treat type 2 diabetes in clinical practice, but the potential evidence needs to be provided. Materials and Methods: Type 2 diabetic model rats were induced by feeding high fat diet (HFD) and intraperitoneal injection of streptozotocin (STZ). The model rats were given ZDQ for 4 weeks. Insulin sensitivity was evaluated by homeostasis model assessment of basal insulin resistance (HOMA-IR) and intraperitoneal glucose tolerance test (IPGTT). Blood insulin and tumour necrosis factor-α (TNF-α) levels as well as SOCS-3 levels in skeletal muscles were analyzed by ELISA. Results: ZDQ significantly decreased fasting blood glucose, ameliorated HOMA-IR and IPGTT, and reduced triglyceride and total cholesterol in type 2 diabetic rats. Moreover, ZDQ remarkably lowered blood TNF-α levels and inhibited SOCS-3 levels in skeletal muscles. Conclusion: The results display that ZDQ performs anti-diabetic functions in type 2 diabetic rats induced by feeding HFD and intraperitoneal injection of STZ.

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Published

2017-03-01

How to Cite

Feng, X.-T., Tang, S.-Y., Jiang, Y.-X., & Zhao, W. (2017). ANTI-DIABETIC EFFECTS OF ZHUODUQING FORMULA, A CHINESE HERBAL DECOCTION, ON A RAT MODEL OF TYPE 2 DIABETES. African Journal of Traditional, Complementary and Alternative Medicines, 14(3), 42–50. https://doi.org/10.21010/ajtcam.v14i3.5

Issue

Vol. 14 No. 3 (2017)

Section

Research Papers

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