January 13, 2017
- Moringa oleifera seeds,
- MCF 10A,
- and Antiproliferative effect.
How to Cite
Adebayo, I., Arsad, H., & Samian, M. (2017). ANTIPROLIFERATIVE EFFECT ON BREAST CANCER (MCF7) OF Moringa oleifera SEED EXTRACTS. African Journal of Traditional, Complementary and Alternative Medicines, 14(2), 282-287. https://doi.org/10.21010/ajtcam.v14i2.30
Background: Moringa oleifera belongs to plant family, Moringaceae and popularly called ―wonderful tree‖, for it is
used traditionally to cure many diseases including cancer in Africa and Asia, however, there is limited knowledge on
cytotoxic activity of Moringa oleifera seeds on MCF7 breast cancer cell. The present study evaluated antiproliferative
effect on MCF7 of the seed.
Materials and Methods: Seeds of Moringa oleifera were grinded to powder and its phytochemicals were extracted
using water and 80% ethanol solvents, part of the ethanolic extract were sequentially partitioned to fractions with four
solvents (hexane, dichloromethane, chloroform, and n-butanol). Antiproliferative effects on MCF7 of the samples were
determined. Finally, potent samples that significantly inhibited MCF7 growth were tested on MCF 10A.
Results: Crude water extract, hexane and dichloromethane fractions of the seeds inhibited the proliferation of MCF7
with the following IC50 values 280 μg/ml, 130 μg/ml and 26 μg/ml respectively, however, of the 3 samples, only
hexane fraction had minimal cytotoxic effect on MCF 10A (IC50 > 400μg/ml).
Conclusion: Moringa oleifera seed has antiproliferative effect on MCF7.