CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS

Authors

  • Yang Wang
  • Weihao Wang
  • Weijun Peng
  • Weiping Liu
  • Weijun Cai
  • Zian Xia
  • Honggeng Zhang
  • Zhihua Xing

DOI:

https://doi.org/10.21010/ajtcam.v14i2.8

Keywords:

Bao-Xin-Tang, cardioprotective, infarction size, anti-inflammatory, anti-oxidative

Abstract

Background: Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role for acute myocardial infarction. The underlying mechanisms were also explored. Materials and Methods: The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory components, and antioxidant activities. Results: The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size. Conclusion: The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties.

Downloads

Published

2017-01-13

How to Cite

Wang, Y., Wang, W., Peng, W., Liu, W., Cai, W., Xia, Z., Zhang, H., & Xing, Z. (2017). CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS. African Journal of Traditional, Complementary and Alternative Medicines, 14(2), 65–74. https://doi.org/10.21010/ajtcam.v14i2.8

Issue

Vol. 14 No. 2 (2017)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.