November 23, 2016
- Oxidative stress.
How to Cite
Mana Salicio, V. M., Fett, C., Salicio, M., MoraesBrand, C. F., Stoppiglia, L., Rezende Fett, W. C., & Botelho, C. (2016). THE EFFECT OF CAFFEINE SUPPLEMENTATION ON TRAINED INDIVIDUALS SUBJECTED TO MAXIMAL TREADMILL TEST. African Journal of Traditional, Complementary and Alternative Medicines, 14(1), 16-23. https://doi.org/10.21010/ajtcam.v14i1.3
Copyright (c) 2016 Viviane Martins Mana Salicio, Carlos Alexandre Fett, Marcos Adriano Salicio, Camila Fernanda Costa Cunha MoraesBrand, Luiz Fabrizio Stoppiglia, WalÃ©ria Christiane Rezende Fett, Clovis Botelho
This work is licensed under a Creative Commons Attribution 4.0 International License.
Background: Intense physical training increases oxidative stress and inflammation, resulting into muscle and cellular
damage. The aim of this study was to analyze the effect of caffeine supplementation on trained young individuals
subjected to two treadmill maximal tests.
Materials and Methods: It was a double-blind and crossover study comprising 24 active individuals within the age
group 18-30 years. The comparisons were conducted: the effect of exercise (week 1 x 2) and caffeine intake (GC x GP)
on thiobarbituric acid (TBARS), interleukin 6 (IL-6), interleukin 10 (IL-10) and superoxide dismutase (SOD) variables
during pre-exercise time (30 min. after caffeine or placebo intake) and post-exercise (5 min after treadmill test).
Results: The comparison between weeks 1 and 2 showed increase in the first week, in the following items: TBARS,
IL-6 and IL-10 in the GC and GP groups. The comparison within the same week showed that GC individuals presented
lower post-exercise TBARS values in the first and second weeks; IL- 6 presented higher post-exercise values in the GC
group in both weeks. The paired analysis comparing pre- and post-exercise, with and without caffeine showed that IL-6
presented higher post-exercise values in the GC group.
Conclusion: Caffeine used by athletes can decrease oxidative stress. The increased IL-6 suggest that this ergogenic
supplement may stimulate muscle hypertrophy, since IL-6 has myokine effect. However, the caffeine effect on IL-6
level and muscle hypertrophy increase should be better investigated in future studies.