EVALUATION OF ANALGESIC, ANTICONVULSANT AND HYPNOTIC ACTIVITIES OF PYRENACANTHIA STAUNDTII

Authors

  • E. O. Awe
  • J. M. Makinde
  • O. A. Wahkeel
  • A. O. Adeloye

Keywords:

Pyrenacanthia staundtii, Analgesic activity, Anticonvulsive, Hypnotic effects.

Abstract

An Aqueous leaf extract of Pyrenacanthia Staundtii (AqPs) was studied for central nervous activities. The extract (100.0 – 400.0 mg/kg i. p). significantly (p<0.05) inhibited acetic-acid induced abdominal constriction, and both the early and or late phases of formalin-induced paw licking in mice. AqPs (100-400mg/kg i.p.) also demonstrated a protective effect against strychnine-induced convulsion. The extract potentiated the hypnotic effect of hexobarbitone following i.p. injection at the dose levels studied. The results suggested that AqPs possesses potential analgesic, anticonvulsive and hypnotic properties.

Author Biographies

E. O. Awe

Department of Pharmacology and Therapeutics, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso

J. M. Makinde

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan

O. A. Wahkeel

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan

A. O. Adeloye

Department of Chemistry, Obafemi Awolowo University Ile-Ife, Nigeria.

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Published

2006-01-07

How to Cite

Awe, E. O., Makinde, J. M., Wahkeel, O. A., & Adeloye, A. O. (2006). EVALUATION OF ANALGESIC, ANTICONVULSANT AND HYPNOTIC ACTIVITIES OF PYRENACANTHIA STAUNDTII. African Journal of Traditional, Complementary and Alternative Medicines, 2(2), 122 –. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/45

Issue

Vol. 2 No. 2 (2005)

Section

Research Papers

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