EVALUATION OF THE ACUTE AND SUBCHRONIC TOXICITY OF ZIWAN BAIBU TANG

Authors

  • Rui-hua Xin
  • Wen-jing Peng
  • Xiao-lei Liu
  • Yong-jiang Luo
  • Gui-bo Wang
  • Chao-ying Luo
  • Jia-sheng Xie
  • Jin-yu Li
  • Ge Liang
  • Ji-fang Zheng

DOI:

https://doi.org/10.21010/ajtcam.v13i3.17

Keywords:

Ziwan Baibu Tang, acute, subchronic, toxicity, herbal

Abstract

Background: Ziwan Baibu Tang (ZBT) is used as a traditional Chinese prescription used in the clinic to cure a variety of respiratory diseases. The objective of this study was to evaluate the acute and subacute toxicity of ZBT. Materials and Methods: Fifty Kunming mice were assigned to 5 groups, and ZBT was administered at different concentrations. Symptoms, mortality and behavioural changes were recorded. Eighty Wistar rats were randomly allocated to 4 treatment groups or a control group for 4 weeks of treatment (half male and half female); general observations and weekly body weight (BW) gain were recorded. At the end of the 4-week experiment, the rats were sacrificed, and blood was collected for haematological and serum biochemical analyses. Samples from the primary organs were fixed in 10% buffered formalin for histopathological studies. Results: The calculated LD50 of acute oral toxicity was 319.16 g/kg BW. After the 4-week treatment, BW did not significantly differ in any of the dose groups, compared with the control group (P>0.05), and the rat blood red blood cell (RBC) and haemoglobin (HGB) levels in each dose group did not significantly differ (P>0.05). In addition, serum urea and creatine levels in each dose group did not significantly differ from those in the control group (P>0.05). Conclusion: These results indicate that ZBT does not possess toxic potential and that both the acute and subchronic toxicity in animals are very low.

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Published

2016-03-15

How to Cite

Xin, R.- hua, Peng, W.- jing, Liu, X.- lei, Luo, Y.- jiang, Wang, G.- bo, Luo, C.- ying, Xie, J.- sheng, Li, J.- yu, Liang, G., & Zheng, J.- fang. (2016). EVALUATION OF THE ACUTE AND SUBCHRONIC TOXICITY OF ZIWAN BAIBU TANG. African Journal of Traditional, Complementary and Alternative Medicines, 13(3), 140–149. https://doi.org/10.21010/ajtcam.v13i3.17

Issue

Vol. 13 No. 3 (2016)

Section

Research Papers

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