ANTIHYPERGLYCEMIC EFFECT OF BRIDELIA NDELLENSIS ETHANOL EXTRACT AND FRACTIONS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Authors

  • S. D. Sokeng
  • B. Rokeya
  • B. Rokeya
  • M. Mostafa
  • M. Mostafa
  • N. Nahar
  • N. Nahar
  • M. Mosihuzzaman
  • M. Mosihuzzaman
  • L. Ali
  • L. Ali
  • P. Kamtchouing
  • P. Kamtchouing

Keywords:

Bridelia ndellensis, hypoglycemic effect, Streptozotocin, diabetes, rats.

Abstract

The effects of the ethanol extract (1.25 g/kg) and fractions (1 g/kg) of Bridelia ndellensis stem bark on the blood glucose levels in streptozotocin-induced types 1 and 2 diabetic rats at different prandial states were studied. The ethanol extract of B. ndellensis had no hypoglycemic effect in type 1 diabetic rats in fasting and postprandial glucose load conditions and, in type 2 diabetic rats in fasting condition. However, the extract, and its ethyl acetate and dichloromethane fractions significantly lowered blood glucose levels in type 2 diabetic rats when fed simultaneously with glucose. The active principles responsible for the antihyperglycaemic effect are concentrated in the ethyl acetate and dichloromethane fractions of the extract.

Author Biographies

S. D. Sokeng

Department of Biological Sciences, University of Ngaoundere, P.O.Box 454 Ngaoundere, Cameroon

B. Rokeya

Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM). 122, Kazi Nazrul Islam Avenue, Dhaka-1000, Bangladesh

B. Rokeya

Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM). 122, Kazi Nazrul Islam Avenue, Dhaka-1000, Bangladesh

M. Mostafa

Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

M. Mostafa

Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

N. Nahar

Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

N. Nahar

Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

M. Mosihuzzaman

Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

M. Mosihuzzaman

Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

L. Ali

Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM). 122, Kazi Nazrul Islam Avenue, Dhaka-1000, Bangladesh

L. Ali

Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM). 122, Kazi Nazrul Islam Avenue, Dhaka-1000, Bangladesh

P. Kamtchouing

Laboratory of Animal Physiology, Faculty of Science, University of Yaounde, P.O.Box 812, Yaounde, Cameroon

P. Kamtchouing

Laboratory of Animal Physiology, Faculty of Science, University of Yaounde, P.O.Box 812, Yaounde, Cameroon

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Published

2006-01-07

How to Cite

Sokeng, S. D., Rokeya, B., Rokeya, B., Mostafa, M., Mostafa, M., Nahar, N., Nahar, N., Mosihuzzaman, M., Mosihuzzaman, M., Ali, L., Ali, L., Kamtchouing, P., & Kamtchouing, P. (2006). ANTIHYPERGLYCEMIC EFFECT OF BRIDELIA NDELLENSIS ETHANOL EXTRACT AND FRACTIONS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 2(2), 94 –. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/42

Issue

Vol. 2 No. 2 (2005)

Section

Research Papers

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