ANXIOLYTIC - LIKE PROPERTIES OF HALLEA CILIATA IN MICE

Authors

  • Njapdounke Kameni Jacqueline Stephanie University of Ngaoundere
  • Nkantchoua Nkamguie Gisele University of Ngaoundere
  • Moto Okomolo Fleur Clarisse Universite de Ngaoundere
  • aiwe Sotoing Germain University of Buea, Cameroon
  • idiki Neteydji Universite de Ngaoundere
  • Pale Simon Universite de Buea
  • Ayissi Mbomo Espoir Rigobert Universite de Yaounde I
  • Ngo Bum Elisabeth University of Yaounde I, Cameroon

DOI:

https://doi.org/10.21010/ajtcam.v13i4.1

Keywords:

Anxiety, herbs, pharmacology, diazepam

Abstract

Background: The aim of the present study was to evaluate the anxiolytic properties of the decoction of stem bark of Hallea ciliata in mice. The decoction of Hallea ciliata is used in traditional medicine in Cameroon to treat diseases like anxiety disorders, fever, infantile convulsions and malaria. Materials and Methods: Stress induced hyperthermia, elevated plus maze, open field and hole-board tests were used. Four different doses of the decoction were administered to mice and their effects were compared to the effects of diazepam and vehicle. Phytochemical characterization of the decoction revealed the presence of alkaloids, flavonoids, tannins and saponins. Results: Administration of Hallea ciliata resulted in a significant decrease of stress induced hyperthermia in mice at the doses of 29.5, 59 and 118 mg/kg. In the elevated plus maze test, Hallea ciliata increased the number of entries and the percentages of entries and time into the open arms, and reduced the number of entries and the percentages of entries and time into the closed arms. In the hole-board test, Hallea ciliata increased the number of both head-dipping and crossing and decreased the latency to the first headdips and rearing. The decoction of Hallea ciliata and diazepam increased locomotion in the open field test. Conclusion: The number of rearing and the mass of fecal boli produced were decreased in mice treated with decoction and diazepam. In conclusion, the results indicated that decoction of Hallea ciliata has anxiolytic-like properties in mice and could potentially be used for anxiety treatment.

Downloads

Published

2016-07-03

How to Cite

Jacqueline Stephanie, N. K., Gisele, N. N., Fleur Clarisse, M. O., Germain, aiwe S., Neteydji, idiki, Simon, P., Espoir Rigobert, A. M., & Elisabeth, N. B. (2016). ANXIOLYTIC - LIKE PROPERTIES OF HALLEA CILIATA IN MICE. African Journal of Traditional, Complementary and Alternative Medicines, 13(4), 1–7. https://doi.org/10.21010/ajtcam.v13i4.1

Issue

Vol. 13 No. 4 (2016)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.

Most read articles by the same author(s)