TOXICITY AND IMMUNOMODULATORY ACTIVITY OF FRACTIONS OF HIBISCUS SABDARIFFA LINN (FAMILY MALVACEAE) IN ANIMAL MODELS

Authors

  • Titilayo Fakeye Department of Clinical Pharmacy & Pharmacy Admin, University of Ibadan, Nigeria

Keywords:

Hibiscus sabdariffa, plant extract and fractions, sub-acute toxicity, immuno-modulatory activity, cytokine production

Abstract

This study evaluated immunomodulatory properties and the sub-acute toxicity profile of two fractions of the aqueous alcoholic extract of the dried calyx of Hibiscus sabdariffa in experimental animals. Immunomodulatory activity was evaluated using red blood cell-induced immunostimulation. The fractions were not found to be toxic after 7-day administration, though there was severe weight loss with the residual water-soluble fraction (RWSF) and weight gain with the ethyl acetate soluble fraction (EAC). The EAC exhibited a significant dose-dependent immunostimulation (p<0.05) higher than that observed for levamisole (positive control). The residual water-soluble fraction exhibited immunostimulatory activity at 100mg/kg body weight. The two fractions caused a significant reduction in production of tissue necrosis factor – alpha and an increase in interleukin 10 (IL-10).

Author Biography

Titilayo Fakeye, Department of Clinical Pharmacy & Pharmacy Admin, University of Ibadan, Nigeria

Senior Lecturer, Clinical Pharmacy Unit

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Published

2008-05-12

How to Cite

Fakeye, T. (2008). TOXICITY AND IMMUNOMODULATORY ACTIVITY OF FRACTIONS OF HIBISCUS SABDARIFFA LINN (FAMILY MALVACEAE) IN ANIMAL MODELS. African Journal of Traditional, Complementary and Alternative Medicines, 5(4), 394–398. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/375

Issue

Vol. 5 No. 4 (2008)

Section

Research Papers

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