AMELIORATING EFFECT OF HAWTHORN (CRATAEGUS OXYACANTHA) AND PHYSICAL EXERCISE ON ACUTE PENICILLIN INDUCED SEIZURES IN GERBILS

Authors

  • Serkan Cakir Abant Izzet Baysal University, Faculty of Agriculture and Natural Sciences
  • Hayriye Orallar Abant Izzet Baysal University, Faculty of Agriculture and Natural Sciences
  • Ayhan Cetinkaya Abant Izzet Baysal University
  • Yıldırım Kayacan Ondokuz Mayis University, Sports Sciences, Faculty of Yasar Dogu
  • Ali Can Onal Bolu KöroÄŸlu State Hospital
  • Arzu Yildirim Abant Ä°zzet Baysal University, Faculty of Agriculture and Natural Sciences
  • Ersin Beyazcicek Düzce University, Faculty of Medicine
  • Selim Benek Abant Ä°zzet Baysal University, Faculty of Medicine
  • Murat Ozkan Abant Ä°zzet Baysal University, Bolu Vocational High School
  • Omer Baris Ince Agriculture and Rural Development Support Institue
  • Nezih Okur Abant Izzet Baysal University, Faculty of Agriculture and Natural Sciences http://orcid.org/0000-0003-2431-0313

DOI:

https://doi.org/10.21010/ajtcam.v13i2.26

Keywords:

Crataegus oxyacantha, physical activity, epilepsy, gerbil

Abstract

The aim of the present study was to assess the effect of Hawthorn (Crataegus oxyacantha) and physical activity. We studied its effect on penicilline induced epilepticus (Pie) in gerbils. Pie was induced by administration of penicilline G (500 IU, ip). The gerbils were divided randomly in four groups (6 animals per each group) and studied as described below: 1) Control group 2) Exercise group (30 min/each day for 8 weeks) (Eg) 3) Extract group, 50mg/kg/day/animal in 1 ml saline, 3 h prior to exercise (Exe) 4) Exercise+Extract + (Exe+Ex). The severity of Pie was observed and recorded. The means of latencies (Mean±SE) were 236±45, 369±36, 386±58 and 433±37 ms in groups of control, Exe, Ex, and Exe+Ex respectively. The mean spike latency significantly (P=0,033 F=3,560) decreased in Exe, Ex and Exe+Ex when compared control. Although spike frequency significantly (P<0.05) diminished in groups of Exe and Ex, no significant decrease was observed in control and Exe+Ex. Similar trend was seen for amplitude values. Spike amplitude values were determined to be significantly (P<0.05) lower than those of control and Exe+Ex.

Author Biographies

Serkan Cakir, Abant Izzet Baysal University, Faculty of Agriculture and Natural Sciences

Poultry Sicence Department

Hayriye Orallar, Abant Izzet Baysal University, Faculty of Agriculture and Natural Sciences

Poultry Sicence Department

Ayhan Cetinkaya, Abant Izzet Baysal University

Experimental Animals Research and Application Center

Arzu Yildirim, Abant Ä°zzet Baysal University, Faculty of Agriculture and Natural Sciences

Department of Field Crops

Ersin Beyazcicek, Düzce University, Faculty of Medicine

Department of Physiology

Selim Benek, Abant Ä°zzet Baysal University, Faculty of Medicine

Department of Physiology

Murat Ozkan, Abant Ä°zzet Baysal University, Bolu Vocational High School

Electricity and Energy Department

Nezih Okur, Abant Izzet Baysal University, Faculty of Agriculture and Natural Sciences

Poultry Farming Department

Downloads

Published

2016-02-05

How to Cite

Cakir, S., Orallar, H., Cetinkaya, A., Kayacan, Y., Onal, A. C., Yildirim, A., Beyazcicek, E., Benek, S., Ozkan, M., Ince, O. B., & Okur, N. (2016). AMELIORATING EFFECT OF HAWTHORN (CRATAEGUS OXYACANTHA) AND PHYSICAL EXERCISE ON ACUTE PENICILLIN INDUCED SEIZURES IN GERBILS. African Journal of Traditional, Complementary and Alternative Medicines, 13(2), 223–228. https://doi.org/10.21010/ajtcam.v13i2.26

Issue

Vol. 13 No. 2 (2016)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.