ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE)

Authors

  • Carolina Roca-Mézquita Universidad Autónoma de Yucatán
  • Manlio Graniel-Sabido Universidad Autónoma de Yucatán
  • Rosa E. Moo-Puc Instituto Mexicano del Seguro Social
  • Lorena V. Leon-Déniz Universidad Autónoma de Yucatán
  • Rubí Gamboa-León Universidad Autónoma de San Luis Potosí
  • Carely Arjona-Ruiz
  • Juan Tun-Garrido Univesidad Autónoma de Yucatán
  • Gumersindo Mirón-López Universidad Autónoma de Yucatán
  • Gonzalo J. Mena-Rejon Universidad Autónoma de Yucatán

DOI:

https://doi.org/10.21010/ajtcam.v13i4.21

Keywords:

Elaeodendron trichotomum, antiprotozoal activity, Celastraceae, tingenone, pristimerin, root bark.

Abstract

Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of Elaeodendron trichotomum, a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases. Materials and methods: Dichloromethane and methanol extracts of leaves, bark and roots of Elaeodendron trichotomum were tested against Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Trypanosoma cruzi. A quantitative HPLC analysis of pristimerin and tingenone was performed. Results: The dichloromethane extract of roots was active against E. histolytica, G. lamblia, T. vaginalis, and T. cruzi, at IC50’s of 0.80, 0.44, 0.46, and 2.68 μg/mL, respectively. The HPLC analysis revealed the presence of tingenone (3.84%) and pristimerin (0.14%). Conclusions: The dichloromethane extract of the roots bark showed significant activity against all screened protozoa.

Author Biographies

Carolina Roca-Mézquita, Universidad Autónoma de Yucatán

Facultad de Química

Manlio Graniel-Sabido, Universidad Autónoma de Yucatán

Facultad de Química

Rosa E. Moo-Puc, Instituto Mexicano del Seguro Social

Unidad de Investigación Médica Yucatán

Lorena V. Leon-Déniz, Universidad Autónoma de Yucatán

Facultad de Medicina Veterinaria y Zootecnia

Juan Tun-Garrido, Univesidad Autónoma de Yucatán

Facultad de Medicina Veterinaria y Zootecnia

Gumersindo Mirón-López, Universidad Autónoma de Yucatán

Facultad de Química

Gonzalo J. Mena-Rejon, Universidad Autónoma de Yucatán

Facultad de Química

Downloads

Published

2016-07-03

How to Cite

Roca-Mézquita, C., Graniel-Sabido, M., Moo-Puc, R. E., Leon-Déniz, L. V., Gamboa-León, R., Arjona-Ruiz, C., Tun-Garrido, J., Mirón-López, G., & Mena-Rejon, G. J. (2016). ANTIPROTOZOAL ACTIVITY OF EXTRACTS OF ELAEODENDRON TRICHOTOMUM (CELASTRACEAE). African Journal of Traditional, Complementary and Alternative Medicines, 13(4), 162–165. https://doi.org/10.21010/ajtcam.v13i4.21

Issue

Vol. 13 No. 4 (2016)

Section

Short communications

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.