ASSESSING EFFECTS OF EQUISETUM RAMOSISSIMUM EXTRACT ON HEMATOLOGICAL AND SERUM BIOCHEMICAL PARAMETERS IN PREGNANT SPRAGUE-DAWLEY RATS

Authors

  • Hana Dawood Alebous
  • Arwa Ali Hudeb
  • Suzanne Ali Sober
  • Rosianna Gray
  • Margaret Dean Johnson

DOI:

https://doi.org/10.21010/ajtcam.v13i3.2

Keywords:

Equisetum ramosissimum extract, Pregnant Sprague-Dawley rats, Haematology, Serum

Abstract

Background: As a medicinal herb, Equisetum ramossisemum has been utilized for centuries as a diuretic and has been recommended for different disorders. The aim of this study was to investigate the maternal toxicity of aerial parts of Equisetum ramosissimum extract on pregnant Sprague-Dawley rats. Methods: Females were mated and the coupling time was recorded at gestation day 0– E0. Four experimental groups I, II, III, and IV, received daily gavage doses of 0 mg, 500 mg, 250 mg, and 125 mg/kg, respectively, of Equisetum ramosissimum extract. Pregnant rats were observed for mortality and toxicological effects during daily treatment. On day E20, samples of blood were withdrawn from the retro-orbital sinus under light ether anaesthesia for haematological and clinical chemistry examinations. Results: Data analyses detected significant differences in biochemical and haematological parameters between the control group and other groups receiving extract. Conclusion: This study constitutes a first approach to defining adverse effects of using Equisetum ramosissimum as a medicinal plant during pregnancy. Daily gavage doses of Equisetum ramosissimum extract produced significant differences in biochemical and haematological parameters in pregnant Sprague-Dawley rats as compared to the control group.

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Published

2016-03-15

How to Cite

Alebous, H. D., Hudeb, A. A., Sober, S. A., Gray, R., & Johnson, M. D. (2016). ASSESSING EFFECTS OF EQUISETUM RAMOSISSIMUM EXTRACT ON HEMATOLOGICAL AND SERUM BIOCHEMICAL PARAMETERS IN PREGNANT SPRAGUE-DAWLEY RATS. African Journal of Traditional, Complementary and Alternative Medicines, 13(3), 16–21. https://doi.org/10.21010/ajtcam.v13i3.2

Issue

Vol. 13 No. 3 (2016)

Section

Research Papers

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