ANTI-INFLAMMATORY EFFECT OF ZANTHOXYLUM BUNGEANUM-CAKE-SEPARATED MOXIBUSTION ON RHEUMATOID ARTHRITIS RATS

Authors

  • Xulu Lei Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Shirui Cheng Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Honglian Peng Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Qin He Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Hongyu Zhu Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Mengqian Xu Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Qinqin Wang Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Li Liu Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Chengshun Zhang Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Qizhi Zhou Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Jian Ying Department of oncology, Chongqing Hospital for Chinese Medicine
  • Fang Zeng Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Haiyan Yin Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine
  • Shuguang Yu Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine

DOI:

https://doi.org/10.21010/ajtcam.v13i1.7

Keywords:

Anti-inflammatory effect, Zanthoxylum bungeanum-cake-separated moxibustion, Aconitum carmichaeli-cake-separated moxibustion, Rheumatoid Arthritis.

Abstract

Background: Zanthoxylum bungeanum-cake-separated moxibustion (ZBCS-moxi), a kind of traditional therapy of moxibustion, has been used in China since 340 B.C. However, its mechanism remains unclear. So, this study was attempted to reveal the anti-inflammatory effect of ZBCS-moxi on rheumatoid arthritis (RA) rats. Methods and Materials: Forty health SD female rats were randomly divided into 4 groups (n=10/group): control group, model group, Zanthoxylum bungeanum-cake-separated moxibustion group (ZBCS-moxi group) and Aconitum carmichaeli-cake-separated moxibustion group (ACCS-moxi group). RA model was induced by injecting 0.1 ml Freund’s complete adjuvant (FCA) into the right hind paw of rats. Eleven days after CFA injection, the rats in ZBCS-moxi group received Zanthoxylum bungeanum- cake-separated moxibustion on Shenshu (BL23), Zusanli (ST36) acupoints and the dorsum right hind paw respectively for 3 weeks. The ACCS-moxi group was used as a positive control, while the rats were treated with Aconitum carmichaeli-cake-separated moxibustion on the same acupoints and courses. After a 3-week treatment, we investigated anti-inflammatory effect by measuring the paw volume, observing the pathologic morphology of synovial membranes and detecting the concentration of IL-1β and TNF-α in serum. Results: Compared to model group, the swollen paw volumes, the synovial hyperplasia and pannus formation of synovial membranes and the concentration of IL-1β and TNF-α in serum decreased obviously (P<0.01, P<0.05) in ZBCS-moxi group, as well as in ACCS-moxi group. However, the swollen paw volumes, the synovial hyperplasia and pannus formation of synovial membranes and the concentration of IL-1β and TNF-α in serum in ZBCS-moxi and ACCS-moxi group did not show significant differences (P>0.05) Conclusions: ZBCS-moxi displays anti-inflammatory effect on RA rats via suppressing the expression of cytokines and has similar effect to ACCS-moxi.

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Published

2015-12-03

How to Cite

Lei, X., Cheng, S., Peng, H., He, Q., Zhu, H., Xu, M., Wang, Q., Liu, L., Zhang, C., Zhou, Q., Ying, J., Zeng, F., Yin, H., & Yu, S. (2015). ANTI-INFLAMMATORY EFFECT OF ZANTHOXYLUM BUNGEANUM-CAKE-SEPARATED MOXIBUSTION ON RHEUMATOID ARTHRITIS RATS. African Journal of Traditional, Complementary and Alternative Medicines, 13(1), 45–52. https://doi.org/10.21010/ajtcam.v13i1.7

Issue

Vol. 13 No. 1 (2016)

Section

Research Papers

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