July 31, 2015
- Oxidative stress,
How to Cite
Altinoz, E., Taskin, E., Oner, Z., Elbe, H., & Arslan, B. (2015). THE EFFECT OF SAFFRON (ITS ACTIVE CONSTITUENT, CROCIN) ON THE CARDIOVASCULAR COMPLICATION AND DYSLIPIDEMIA IN STREPTOZOTOCIN INDUCED DIABETIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 12(5), 1-7. https://doi.org/10.21010/ajtcam.v12i5.1
Background: Diabetes mellitus (DM) causes serious complications such as coronary heart disease, atherosclerosis, nephropathy, retinopathy
Materials and Methods: Rats were randomly divided into three groups each containing 10 rats; control group, DM group; DM+crocin group.
Normal saline was administered in the control and DM groups, and crocin was administered in DM+crocin group at a dose of 20 mg/kg bw/day
for 21 days. Trunk blood and the hearth tissue were collected for histopathological and biochemical examination.
Results: DM led to increment of MDA levels (p<0.05) and the serum levels of total cholesterol, TG, LDL and VLDL (p<0.05) and decrease of
GSH levels (p<0.01) compared to control group in serum and heart tissue. Diabetic rats were treated with crocin, MDA levels (p<0.05) and the
levels of total cholesterol, TG and VLDL decreased significantly, but GSH levels (p<0.05) increased remarkably compared to DM rats.
Statistically significant increase in histopathological damage score was found in the DM group (p<0.0001). Histopathological changes markedly
regressed in DM+crocin group.
Conclusion: Our results showed that crocin might prevent diabetes induced cardiovascular complications by reduction of oxidative stress and