Vol 12 No 5 (2015)
Research Papers

THE EFFECT OF SAFFRON (ITS ACTIVE CONSTITUENT, CROCIN) ON THE CARDIOVASCULAR COMPLICATION AND DYSLIPIDEMIA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Emre Taskin
Bio
Zulal Oner
Bio
Hulya Elbe
Bio
Belkis Atasever Arslan
Bio
Published July 31, 2015
Keywords
  • Oxidative stress,
  • MDA,
  • GSH,
  • crocin,
  • Diabetes,
  • dislipidemia
  • ...More
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How to Cite
Altinoz, E., Taskin, E., Oner, Z., Elbe, H., & Arslan, B. (2015). THE EFFECT OF SAFFRON (ITS ACTIVE CONSTITUENT, CROCIN) ON THE CARDIOVASCULAR COMPLICATION AND DYSLIPIDEMIA IN STREPTOZOTOCIN INDUCED DIABETIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 12(5), 1-7. https://doi.org/10.21010/ajtcam.v12i5.1

Abstract

Background: Diabetes mellitus (DM) causes serious complications such as coronary heart disease, atherosclerosis, nephropathy, retinopathy and neuropathy. Materials and Methods: Rats were randomly divided into three groups each containing 10 rats; control group, DM group; DM+crocin group. Normal saline was administered in the control and DM groups, and crocin was administered in DM+crocin group at a dose of 20 mg/kg bw/day for 21 days. Trunk blood and the hearth tissue were collected for histopathological and biochemical examination. Results: DM led to increment of MDA levels (p<0.05) and the serum levels of total cholesterol, TG, LDL and VLDL (p<0.05) and decrease of GSH levels (p<0.01) compared to control group in serum and heart tissue. Diabetic rats were treated with crocin, MDA levels (p<0.05) and the levels of total cholesterol, TG and VLDL decreased significantly, but GSH levels (p<0.05) increased remarkably compared to DM rats. Statistically significant increase in histopathological damage score was found in the DM group (p<0.0001). Histopathological changes markedly regressed in DM+crocin group. Conclusion: Our results showed that crocin might prevent diabetes induced cardiovascular complications by reduction of oxidative stress and dyslipidemia.