APOPTOSIS INDUCTION OF CENTELLA ASIATICA ON HUMAN BREAST CANCER CELLS

Authors

  • Suboj Babykutty SCTIMST
  • Jose Padikkala Amala Cancer Research Centre
  • P. P. Sathiadevan RGCB
  • Vinod Vijayakurup RGCB
  • T. K. Abdul Azis SCTIMST
  • Priya Srinivas
  • Srinivas Gopala

Keywords:

Apoptosis, Cancer, Centella asiatica

Abstract

The present study evaluated the ability of methanolic extract of Centella asiatica (Linn) Urban (Umbelliferae) to induce apoptosis in different cancer cell lines. MCF-7 cells emerged as the most sensitive cell line for in vitro growth inhibitory activity. C. asiatica extract induced apoptosis in MCF-7 cells as indicated by nuclear condensation, increased annexin staining, loss of mitochondrial membrane potential and induction of DNA breaks identified by TUNEL reactivity. It is possible that the use of C. asiatica extract as a component in herbal medicines could be justifiable.

Author Biographies

Suboj Babykutty, SCTIMST

MSc, MPhil, Department of Biochemistry

Jose Padikkala, Amala Cancer Research Centre

Professor

P. P. Sathiadevan, RGCB

MSc, Molecular Medicine & Cancer Biology

Vinod Vijayakurup, RGCB

Scientist B, Molecular Medicine & Cancer Biology

T. K. Abdul Azis, SCTIMST

Scientist C, Department of Biochemistry

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Published

2008-10-24

How to Cite

Babykutty, S., Padikkala, J., Sathiadevan, P. P., Vijayakurup, V., Abdul Azis, T. K., Srinivas, P., & Gopala, S. (2008). APOPTOSIS INDUCTION OF CENTELLA ASIATICA ON HUMAN BREAST CANCER CELLS. African Journal of Traditional, Complementary and Alternative Medicines, 6(1), 9–16. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/304

Issue

Vol. 6 No. 1 (2009)

Section

Research Papers

License

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