ANTI-GIARDIA ACTIVITY OF HEXANE EXTRACT OF CITRUS AURANTIFOLIA (CHRISTIM) SWINGLE AND SOME OF ITS CONSTITUENTS

Authors

  • Irma Guadalupe Domínguez-Vigil Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.
  • María del Rayo Camacho-Corona Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.
  • J. Antonio Heredia-Rojas Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.
  • Javier Vargas-Villarreal Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey Nuevo León 64000. México
  • Abraham O. Rodríguez-De la Fuente Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.
  • Omar Heredia-Rodríguez Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.
  • Benito David Mata-Cardenas Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.

DOI:

https://doi.org/10.4314/ajtcam.v12i2.10

Keywords:

Antigiardial, Citrus aurantifolia, antiprotozoal activity, Giardia lamblia

Abstract

Giardia lamblia is a parasite that causes giardiasis in humans and other mammals. The common treatment includes different classes of drugs, which were described to produce unpleasant side effects. Citrus aurantifolia, popularly known as lima, is a plant used in the traditional medicine to treat gastrointestinal symptoms. The aim of the present study was to evaluate the anti-Giardia activity of 10 pure compounds obtained from a hexanic extract of Mexican lime, on the basis of trophozoite growth inhibition. 4-hexen-3-one, citral and geraniol showed IC50 values of 34.2, 64.5 and 229.49 µg/ml in axenic cultures after 24 h of incubation, respectively. The obtained results lead us to propose that these compounds from C. aurantifolia have potential for use as therapeutic agents against giardiasis.

Author Biographies

Irma Guadalupe Domínguez-Vigil, Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.

Professor

María del Rayo Camacho-Corona, Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.

Professor

J. Antonio Heredia-Rojas, Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.

Professor

Javier Vargas-Villarreal, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey Nuevo León 64000. México

Professor

Abraham O. Rodríguez-De la Fuente, Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.

Professor

Omar Heredia-Rodríguez, Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.

Professor

Benito David Mata-Cardenas, Universidad Autónoma de Nuevo León, Facultad de Ciencias Químicas, Av. Universidad S/N Ciudad Universitaria, San Nicolás de los Garza, Nuevo León, 66451. México.

Professor

Downloads

Published

2015-03-07

How to Cite

Domínguez-Vigil, I. G., Camacho-Corona, M. del R., Heredia-Rojas, J. A., Vargas-Villarreal, J., Rodríguez-De la Fuente, A. O., Heredia-Rodríguez, O., & Mata-Cardenas, B. D. (2015). ANTI-GIARDIA ACTIVITY OF HEXANE EXTRACT OF CITRUS AURANTIFOLIA (CHRISTIM) SWINGLE AND SOME OF ITS CONSTITUENTS. African Journal of Traditional, Complementary and Alternative Medicines, 12(2), 55–59. https://doi.org/10.4314/ajtcam.v12i2.10

Issue

Vol. 12 No. 2 (2015)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.

Most read articles by the same author(s)