EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF COMPOUND HERBS PUXING YINYANG SAN

Authors

  • Lei Wang
  • Xurong Wang
  • Jingyan Zhang
  • Zhiqiang Yang
  • Youbin Liu
  • Dongan Cui
  • Zhe Qin
  • Jiaren Meng
  • Xiaojun Kong
  • Xuezhi Wang
  • Jianxi Li

DOI:

https://doi.org/10.21010/ajtcam.v12i4.22

Keywords:

Puxing Yinyang San, analgesic activity, anti-inflammatory activity, herb. Introduction

Abstract

Background: Bovine mastitis is one of the most relevant and problematic diseases to treat and control in practice. Puxing Yinyang San (PYS) is a compound of herbs to treat bovine mastitis in China. This study was performed to evaluate the analgesic and anti-inflammatory activities of PYS in mice and rats. Materials and Methods: The analgesic and anti-inflammatory activities of PYS were determined using acetic acid-induced writhing response, hot plate test, xylene-induced ear swelling test, carrageenan-induced paw edema test, and acetic acid-induced capillary permeability and leukocyte infiltration test with oral doses of 155, 310 and 620 mg/kg·bw in mice or rats. Results: The acetic acid-induced writhing response was dose-dependently inhibited by oral administration of PYS and the latency time to thermal stimuli was increased in the hot plate test, especially 90 minutes after treatment. In the xylene-induced ear swelling, PYS significantly decreased swelling degree in a dose-dependent manner. Additionally, PYS significantly suppressed the peritoneal capillary permeability and leukocyte infiltration in mice induced by intraperitoneal injection of acetic acid. PYS also significantly reduced the carrageenan-induced rat paw edema at 2, 3, and 4 h after the carrageenan injection. The results suggested that PYS possessed significant analgesic and anti-inflammatory activities. Conclusion: This study was the first to demonstrate that oral administration of PYS might play an important role in the process of analgesia and anti-inflammation, supporting its treatment for mastitis. Future investigations will focus on the broader involvement of the ingredients and mechanisms responsible for pharmacological activities of PYS.

Author Biography

Jianxi Li

Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R. China

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Published

2015-06-27

How to Cite

Wang, L., Wang, X., Zhang, J., Yang, Z., Liu, Y., Cui, D., Qin, Z., Meng, J., Kong, X., Wang, X., & Li, J. (2015). EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF COMPOUND HERBS PUXING YINYANG SAN. African Journal of Traditional, Complementary and Alternative Medicines, 12(4), 151–160. https://doi.org/10.21010/ajtcam.v12i4.22

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Section

Research Papers