STUDIES ON EFFECT OF PIPERINE ON ORAL BIOAVAILABILITY OF AMPICILLIN AND NORFLOXACIN

Authors

  • Kunchithapatham Janakiraman ANNAMALAI UNIVERSITY
  • Rajappan Manavalan Annamalai University

Keywords:

Ampicillin, Bioavailability, Norfloxacin, Phamacokinetics, Piperine, Piper nigrum.

Abstract

Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t½ of the above antibiotics in animal model.

Author Biographies

Kunchithapatham Janakiraman, ANNAMALAI UNIVERSITY

Sl. Gr. Lecturer Department Of Pharmacy Annamali University.

Rajappan Manavalan, Annamalai University

Head Of Department Department Of Pharmacy Annamali University.

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Published

2008-04-08

How to Cite

Janakiraman, K., & Manavalan, R. (2008). STUDIES ON EFFECT OF PIPERINE ON ORAL BIOAVAILABILITY OF AMPICILLIN AND NORFLOXACIN. African Journal of Traditional, Complementary and Alternative Medicines, 5(3), 257–262. Retrieved from https://journals.athmsi.org/index.php/ajtcam/article/view/284

Issue

Vol. 5 No. 3 (2008)

Section

Research Papers

License

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